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International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i6.20
pages 477-487

Anti-Inflammatory Effects of Extracts from the Medicinal Mushrooms Hypsizygus marmoreus and Pleurotus eryngii (Agaricomycetes)

Rao-Chi Chien
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.; National Chung Hsing University/University of California Davis Plant and Food Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, R.O.C.; Agricultural Biotechnology Center, National Chung Hsing University/University of California Davis Plant and Food Biotechnology Center, Taiwan, R.O.C.
Yi-Chi Yang
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan, R.O.C.
Eric Icheng Lai
Department of Biotechnology, Hungkuang University, Taichung, Taiwan, R.O.C.
Jeng-Leun Mau
Department of Food Science and Biotechnology National Chung-Hsing University 250 Kuokuang Road, Taichung 40227, Taiwan, ROC

要約

The inflammatory response caused by the immune system can be defensive, but a long-term inflammatory response may lead to the development of many different chronic diseases. In this study, 4 extracts were prepared from Hypsizygus marmoreus and Pleurotus eryngii fruiting bodies and used to evaluate their effects on inflammation-related mediators in RAW 264.7 cells. The 4 extracts contained substantial amounts of phenolic compounds (5.10-9.96 mg/g extract) and flavonoids (1.92-5.13 mg/g extract). With the extracts added, the production of nitric oxide and the proinflammatory interleukin (IL)-6 could be effectively suppressed, whereas the production of the proinflammatory tumor necrosis factor-α and IL-1Β could be relatively suppressed. In addition, production of the anti-inflammatory cytokine IL-10 could be increased. Overall, these mushrooms might be capable of amending inflammatory responses.