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International Journal of Medicinal Mushrooms
インパクトファクター: 1.211 5年インパクトファクター: 1.394 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i2.40
pages 129-134

Effects of Polysaccharides Isolated from Agaricus brasiliensis (Agaricomycetideae) on Splenic Hematopoiesis in Mice

Yoshiaki Fujimiya
Division of Biotechnology, Sumitomo Forestry Tsukuba Research Institute, 3-2, Midorigahara, Tsukuba; and Department of Microbiology and Immunology, Hachinohe University School of Human Health Sciences, Hachinohe, Aomori 031-8566, Japan
Debra S. Groveman
Veterans Administration Hospital, White River Junction, VT 05009
Yoshihiro Takei
INA Research, K.K. Ina, Nagano 399-4501, Japan
Youichi Suzuki
Suzuki Neurosurgery Medical Center, Watari, Miyagi, 989-2301, Japan
Masahide Noji
Department of Clinical Nutrition, Suzuka University of Medical Science, Kishioka-cho, Suzuka, Japan

要約

The administration of ethanol-soluble, boiling water-soluble, and ammonium oxalate-insoluble fractions (essentially β-1, 6-D glucose) isolated from the fruiting bodies of Agaricus brasiliensis into C3H/HeN mice resulted in a marked proliferation of cells of multicell lineages in the splenic compartment. Phenotypically increased expression of NK1.1+ on lymphoid cells and histologically increased proliferations of megakaryocytic progenitor cells were seen in the splenic compartment. These results indicate that β-1, 6-D polysaccharides may play a critical role in the maintenance of hematopoietic cells for compromised patients at the risk of infection associated with malignancy.


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