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International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

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International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v12.i3.10
pages 227-234

Aqueous Extract of Culinary-Medicinal Royal Sun Mushroom, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae) Effects on Immunodepression in Mice

Elisabete Fantuzzi
Departamento de Produção Vegetal, Centro de Ciências Agrärias, Universidade Federal do Espirito Santo, ES, Brasil
Lucilene Rezende Anastacio
Programa de Pós- Graduação em Saúde do Adulto, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Jacques Robert Nicoli
Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Sergio Oliveira de Paula
Departamento de Biologia Geral, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, MG, Brasil
Rosa Maria Esteves Arantes
Departamento de Patologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil
Sergio Luis Pinto da Matta
Departamento de Biologia Geral, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, MG, Brasil
Maria Cristina Dantas Vanetti
Departamento de Microbiologia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Viçosa, MG, Brasil

要約

Agaricus brasiliensis S. Wasser et al. (=Agaricus blazei Murrill sensu Heinem.) has received attention in folk medicine due to its possible medicinal values. This study evaluated the effects of an A. brasiliensis aqueous extract on weight gain; bacterial translocation; intestinal levels of total sIgA; serum levels of tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), and interleukin-10 (IL-10); splenic index; and histology of the ileum, spleen, and liver of mice experimentally immunodepressed with cyclophosphamide. A. brasiliensis aqueous extract was administrated ad libitum and by intragastric gavage in mice aged 6 to 7 weeks, 2 weeks before the first dose of cyclophosphamide and until the 23rd day of the experiment. Experimental immunodepression was confirmed by body-weight loss during the last week of the experiment, reduction of the splenic index, and altered splenic histology. However, Gram-negative bacteria translocation was not observed in the immunodepressed animal groups during the experimental period. Alterations due to immunodepression treatment and cited above were not influenced by oral treatment with A. brasiliensis extract. Similarly, treatment with A. brasiliensis extract did not influence intestinal IgA levels or TNF-α, IFN-γ, and IL-10 levels in serum. Under the conditions used in the present study, alterations obtained by experimental immunodepression in mice were not reduced by oral treatment with A. brasiliensis extract.


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