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International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v13.i2.10
pages 101-107

Characterization of Blood (β-1,3-glucan and Anti-(β-glucan Antibody in Hemodialysis Patients Using Culinary-Medicinal Royal Sun Agaricus, Agaricus brasiliensis S. Wasser et al. (Agaricomycetideae)

Ken-Ichi Ishibashi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Masaharu Yoshida
Renal Unit of the Department of Internal Medicine, Hachiouji Medical Center of Tokyo Medical University, Hachioji, Tokyo
Iwao Nakabayashi
Renal Unit of the Department of Internal Medicine, Hachiouji Medical Center of Tokyo Medical University, Hachioji, Tokyo
Noriko Yoshikawa
Renal Unit of the Department of Internal Medicine, Hachiouji Medical Center of Tokyo Medical University, Hachioji, Tokyo
Noriko N. Miura
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Naohito Ohno
Tokyo University of Pharmacy and Life Sciences School of Pharmacy, Lab Immunopharmacological and Microbiological Production, 1432-1 Horinouchi, Hachioji Tokyo, 192-0392, Japan

要約

β-glucan is a major component of fungal cell walls and shows various immunopharmacological activities including antitumor activity. Previously, we detected anti-β-glucan antibody in human sera. Anti-β-glucan antibody participates in the immune response to fungal cell wall β-glucan. Patients on dialysis are at high risk of infection including fungal infections. We examined the plasma β-glucan level and the titer of anti-β-glucan antibody in dialysis patients. We measured plasma β-1,3-glucan concentrations with the limulus G test and anti-β-glucan antibody titers by ELISA with Candida β-glucan-coated plates. We also examined the influence of the period of dialysis and the kind of dialysis membrane. The patients were positive for β-1,3-glucan in their plasma. The anti-β-glucan antibody titer was lower in the dialysis patients than in healthy volunteers. Long-term dialysis patients showed lower anti-β-glucan antibody titers than short-term dialysis patients. No significant difference was found between the kinds of dialysis membrane. The titer of anti-β-glucan antibody as recognition molecule of β-glucan was low in dialysis patients compared with healthy volunteers. This is likely to be one factor explaining the sensitivity to infection of the dialysis patients. An appropriate application of culinary-medicinal mushroom such as Agaricus brasiliensis has potential for the prevention of fungal infection in dialysis patients.