ライブラリ登録: Guest
International Journal of Medicinal Mushrooms

年間 12 号発行

ISSN 印刷: 1521-9437

ISSN オンライン: 1940-4344

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.2 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 1.4 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.3 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00066 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.34 SJR: 0.274 SNIP: 0.41 CiteScore™:: 2.8 H-Index: 37

Indexed in

Medicinal Mushroom Lingzhi or Reishi, Ganoderma lucidum (W.Curt.:Fr.) P. Karst., β-Glucan Induces Toll-like Receptors and Fails to Induce Inflammatory Cytokines in NF-κB Inhibitor-Treated Macrophages

巻 13, 発行 3, 2011, pp. 213-225
DOI: 10.1615/IntJMedMushr.v13.i3.10
Get accessGet access

要約

β-Glucan of medicinal Lingzhi or Reishi mushroom, Ganoderma lucidum (BGG), possesses immunostimulatory and anti-tumor activities. Innate immune cells are activated by the binding of β-glucan to the dectin-1 receptor. The present study investigated the immunostimulating activities of BGG, including binding to dectin-1, secretion of cytokines and reactive oxygen species, and induction of Toll-like receptors (TLRs) in RAW264.7 mouse macrophages. Reverse transcription−polymerase chain reaction and flow cytometry were used for the cytokine and TLR analyses. A mouse inflammation antibody array was used for protein-level cytokine analysis. BGG bound to dectin-1 and induced RAW264.7 cell secretion of several cytokines, including granulocyte colony-stimulating factor, interleukin (IL)-6, regulated upon activation normal T cell expressed and secreted (RANTES), tissue inhibitor of metalloproteinase-1, and tumor necrosis factor-alpha. The secretion of these cytokines was further increased by the addition of lipopolysaccharide (LPS). BGG also induced both nitric oxide and inducible nitric oxide synthase (iNOS). Treatment with an inhibitor of nuclear factor-kappa B (NF-κB) reduced the induction of IL-1, IL-6, and iNOS in a concentration-dependent manner. Expressions of TLR2, TLR4, and TLR6 were increased by BGG treatment, and addition of LPS induced further induction of TLR4 and TLR6. Our result indicates that BGG induces macrophage secretion of inflammatory cytokines, which can be potentiated by the presence of LPS, likely by binding to dectin-1 and TLR-2/6 receptors, which activate NF-κB and prompt the secretion of cytokines.

によって引用された
  1. Kim Hyung Sook, Kim Yeon Jin, Lee Hong Kyung, Ryu Hwa Sun, Kim Ji Sung, Yoon Mi Jung, Kang Jong Soon, Hong Jin Tae, Kim Youngsoo, Han Sang-Bae, Activation of macrophages by polysaccharide isolated from Paecilomyces cicadae through toll-like receptor 4, Food and Chemical Toxicology, 50, 9, 2012. Crossref

  2. Batbayar Sainkhuu, Lee Dong-Hee, Kim Ha-Won, Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1, Biomolecules and Therapeutics, 20, 5, 2012. Crossref

  3. Du Bin, Lin Chengyuan, Bian Zhaoxiang, Xu Baojun, An insight into anti-inflammatory effects of fungal beta-glucans, Trends in Food Science & Technology, 41, 1, 2015. Crossref

  4. Rui Ke, Tian Jie, Tang Xinyi, Ma Jie, Xu Ping, Tian Xinyu, Wang Yungang, Xu Huaxi, Lu Liwei, Wang Shengjun, Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden, Immunologic Research, 64, 4, 2016. Crossref

  5. Zhao Ruolin, Chen Qilong, He Yu-min, The effect of Ganoderma lucidum extract on immunological function and identify its anti-tumor immunostimulatory activity based on the biological network, Scientific Reports, 8, 1, 2018. Crossref

  6. Liang Peihe, Guo Jia, Li Shadan, Guan Qiunong, Vanderheyden Terry, So Alan, Wang Yuzhuo, Chen Tao, Du Caigan, Prevention of Prostate Tumor Development by Stimulation of Antitumor Immunity Using a Standardized Herbal Extract (Deep Immune®) in TRAMP Mice, Evidence-Based Complementary and Alternative Medicine, 2018, 2018. Crossref

  7. Sukhatme Vidula V., Ramalingam Suresh S., Ahmed Rafi, Sukhatme Vikas P., Repurposing Food and Drug Administration–Approved Drugs to Promote Antitumor Immunity, The Cancer Journal, 25, 2, 2019. Crossref

  8. Wang Xin, Lin Zhibin, Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism, in Ganoderma and Health, 1182, 2019. Crossref

  9. Benson Kathleen F., Stamets Paul, Davis Renee, Nally Regan, Taylor Alex, Slater Sonya, Jensen Gitte S., The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro, BMC Complementary and Alternative Medicine, 19, 1, 2019. Crossref

  10. Jin Xin, Zhang Man, Yang Yin-feng, Saccharomyces cerevisiae β-glucan-induced SBD-1 expression in ovine ruminal epithelial cells is mediated through the TLR-2-MyD88-NF-κB/MAPK pathway, Veterinary Research Communications, 43, 2, 2019. Crossref

  11. Xiao Zhiyong, Zhou Wenxia, Zhang Yongxiang, Fungal polysaccharides, in Pharmacological Advances in Natural Product Drug Discovery, 87, 2020. Crossref

  12. Younger Jarred, Donovan Emily K., Hodgin Kathleen S., Ness Timothy J., A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum), International Journal of Environmental Research and Public Health, 18, 7, 2021. Crossref

  13. Zhang Yazhuo, Liu Xinning, Zhao Jun, Wang Jie, Song Qiaoling, Zhao Chenyang, The phagocytic receptors of β-glucan, International Journal of Biological Macromolecules, 205, 2022. Crossref

3957 記事の閲覧数 78 記事のダウンロード 記事の統計
3957 記事の閲覧数 78 記事のダウンロード 13 Crossref 引用数 Google
Scholar
引用数

類似内容の記事:

Cooperative Effect of the Lipopolysaccharide and Culinary-Medicinal Cauliflower Mushroom Sparassis crispa (Wulf.) Fr. (Aphyllophoromycetideae)-Derived β-Glucan on Inflammatory Cytokine Secretion by the Murine Macrophage Cell Line International Journal of Medicinal Mushrooms, Vol.11, 2009, issue 1
Ha Won Kim, Sung In Kim, In Soo Ko, Hyuk Gu Park, Gye Hyung Cho
Potentiation of Antitumor Activity by Antibody Drugs and Mushroom-Derived β-Glucans in Natural Killer Cell-Mediated Tumoricidal Activities against Non-Hodgkin's B-Cell Lymphoma International Journal of Medicinal Mushrooms, Vol.25, 2023, issue 3
Hiromi Momose, Yoshiyuki Adachi, Naohito Ohno, Rui Tada, Fumiyasu Momose
Hot Water Extract of the Sclerotium of Polyporus rhinocerus Cooke Enhances the Immune Functions of Murine Macrophages International Journal of Medicinal Mushrooms, Vol.13, 2011, issue 3
Cuixia Guo, Ka-Hing Wong, Peter Chi Keung Cheung
TLR9 Knockdown Alleviates Sepsis via Disruption of MyD88/NF-κB Pathway Activation Critical Reviews™ in Immunology, Vol.44, 2024, issue 2
Jiajian Ye, Lili Jiang, Lili Li , Shuzhu Mao
Inositol Hexaphosphate Induces Apoptosis by Coordinative Modulation of P53, Bcl-2 and Sequential Activation of Caspases in 7,12 Dimeth-ylbenz [a] anthracene Exposed Mouse Epidermis Journal of Environmental Pathology, Toxicology and Oncology, Vol.27, 2008, issue 3
Jaya Singh, Krishna P. Gupta
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集 価格及び購読のポリシー Begell House 連絡先 Language English 中文 Русский Português German French Spain