ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.211 5年インパクトファクター: 1.394 SJR: 0.433 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushrooms.v18.i12.50
pages 1105-1114

Renoprotective Effects of Shout Camphor Medicinal Mushroom (Taiwanofungus camphorates, Basidiomycetes) Mycelia on Several Media in Mice with Chronic Kidney Disease

Shu-Chi Wang
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan
Chih-Hui Yang
Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan
Alexandru Mihai Grumezescu
Research Institute of the University of Bucharest, Life, Environmental and Earth Sciences, Bucharest, Romania
Yu-Mei Lin
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan
Keng-Shiang Huang
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan
Wei-Ting Wang
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan
Hsin-Yi Su
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan
Cing-Yan Jhang
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan
Ruo-Yun Chung
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan
Jiun-Hua Chou
The School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung, Taiwan; Department of Biological Science and Technology, I-Shou University, Kaohsiung, Taiwan

要約

Taiwanofungus camphoratus has been widely used in Taiwan as a folk medicine to prevent and treat liver diseases, diarrhea, abdominal pain, itchy skin, and hypertension. Recent studies have shown that T. camphoratus mycelia extracts exert anti-inflammatory and antioxidant effects on some types of renal disease, but the effect of T. camphoratus mycelia on chronic kidney disease (CKD) remains unclear. In this study we used the Bioresource Collection and Research Center (BCRC) medium and modified media (e.g., BCRC+A, HKS1, and HKS1+A media) to incubate T. camphorates mycelia and detect the feasible benefits of renal protection in mice with CKD. Five groups of mice with a partial nephrectomy (each mouse weighed approximately 30 g) received a daily administration of different media-treated T. camphoratus mycelia water solutions (3 mg dried mycelia dissolved in 0.3 mL water) by oral gavage for 30 days, while a control group received distilled water. The results show that progressive increased blood urea nitrogen and serum creatinine were significantly inhibited in the HKS1+A group on days 10 and 30. Plasma total protein was effectively increased in the HKS1 and HKS1+A groups. The BCRC and BCRC+A groups exhibited no obvious improvement in renal function. The results suggest that the HKS1+A medium provides the optimal effect in preventing the deterioration of kidney function and might have a renoprotective effect on CKD.