ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.716 CiteScore™: 2.6

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

巻:
巻 22, 2020 巻 21, 2019 巻 20, 2018 巻 19, 2017 巻 18, 2016 巻 17, 2015 巻 16, 2014 巻 15, 2013 巻 14, 2012 巻 13, 2011 巻 12, 2010 巻 11, 2009 巻 10, 2008 巻 9, 2007 巻 8, 2006 巻 7, 2005 巻 6, 2004 巻 5, 2003 巻 4, 2002 巻 3, 2001 巻 2, 2000 巻 1, 1999

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v10.i4.10
pages 293-302

Ostreolysin, a Cytolytic Protein from Culinary-Medicinal Oyster Mushroom Pleurotus ostreatus (Jacq.: Fr.) P. Kumm. (Agaricomycetideae), and Its Potential Use in Medicine and Biotechnology

Katja Rebolj
Department of Biology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia
Kristina Sepcic
Department of Biology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia

要約

Ostreolysin is a 15-kDa cytolytic protein from the edible oyster mushroom Pleurotus ostreatus. It belongs to the aegerolysin family of small acidic proteins found in bacteria, fungi, and plants, but its biological role is not known. However, its appearance at the stage of primordial formation and its occurrence in peripheral parts of the fruiting bodies and lamellae suggest an involvement in the process of differentiation of hyphae and formation of basidia and spores of the mushroom. Its ability to induce fructification and enhance the yield of young oyster mushrooms after external application to the mushroom mycelium suggests that ostreolysin could be applied in biotechnological processes associated with mushroom farming. This protein is also able to induce the formation of transmembrane pores in natural and artificial lipid membranes. The process of cell lysis results from the specific interaction of ostreolysin with cholesterol-enriched raft-like membrane domains, which, however, differ from those binding caveolin or cholera toxin subunit B. Immunolocalization studies suggest that nontoxic mutants of ostreolysin could be used as specific markers for cholesterol-rich raft-like membrane domains and for studies of lipid raft heterogeneity.


Articles with similar content:

Lignocellulose and White-Rot Basidiomycetes: Some Strategies for Their Potential Utilization
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
George Kvesitadze, Vladimir I. Elisashvili
The Development of the Antiviral Drug RC 28 from Rozites caperata (Pers.: Fr.) P. Karst. (Agaricomycetideae)
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Frank F. Piraino
Chemoprevention of Colon Cancer by iNOS-Selective Inhibitors
Onco Therapeutics, Vol.3, 2012, issue 2
Chinthalapally V. Rao, Naveena B. Janakiram
Biotechnological Potential of Mushrooms: Drugs and Dye Production
International Journal of Medicinal Mushrooms, Vol.7, 2005, issue 3
Girish Tidke, Mahendra K. Rai
Gene Regulation Associated with Apoptosis
Critical Reviews™ in Eukaryotic Gene Expression, Vol.7, 1997, issue 1-2
Barbara A. Osborne, Birgit M. Jehn