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International Journal of Medicinal Mushrooms
インパクトファクター: 1.423 5年インパクトファクター: 1.525 SJR: 0.431 SNIP: 0.661 CiteScore™: 1.38

ISSN 印刷: 1521-9437
ISSN オンライン: 1940-4344

International Journal of Medicinal Mushrooms

DOI: 10.1615/IntJMedMushr.v8.i4.40
pages 329-342

Effect of Culture Conditions on the Chemical Composition and Biological Activities of Agaricus brasiliensis S.Wasser et al. (Agaricomycetideae)

Satoshi Hashimoto
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
Akiko M. Akanuma
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
Masuro Motoi
Toei Pharmaceutical Co. Ltd., 2-5-3 Iguchi, Mitaka, Tokyo 181-0011; Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan
Nobuhiro Imai
Guinishi Alimentary Production Export-and-Import Limited Company, Estrada Dos Fernandes 2563, Suzano, Sao Paulo, Brazil
Carlos A. Rodrignes
Guinishi Alimentary Production Export-and-Import Limited Company, Estrada Dos Fernandes 2563, Suzano, Sao Paulo, Brazil
Sachiko Nameda
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan
Noriko N. Miura
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
Yoshiyuki Adachi
Laboratory for Immunopharmacology of Microbial Products, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Naohito Ohno
Tokyo University of Pharmacy and Life Sciences School of Pharmacy, Lab Immunopharmacological and Microbiological Production, 1432-1 Horinouchi, Hachioji Tokyo, 192-0392, Japan

要約

Agaricus brasiliensis is included in many kinds of health foods. Both the fruit body and mycelium, cultured in various countries from various strains and using various production processes, are supplied. In the present study, we planned to compare the chemical properties and biological activities of A. brasiliensis cultured under different conditions, i.e., indoors in a house (IC) and outside on a field (OC), using the same strain and the same production process. Polysaccharide fractions prepared from IC and OC had similar structural features and biological activity, as assessed by component sugar analysis, nuclear magnetic resonance, and antitumor activity in vivo. In contrast, the protein fractions were qualitatively different, i.e., specific protein spots were detected by two-dimensional polyacrylamide gel electrophoresis, and the enzyme activities, especially laccase, polyphenoloxidase, peroxidase, and beta-glucanase activities, were different. These facts strongly suggested that the culture conditions of medicinal mushrooms are keys for their pharmacological activity assessment.