ライブラリ登録: Guest
Begell Digital Portal Begellデジタルライブラリー 電子書籍 ジャーナル 参考文献と会報 リサーチ集
Critical Reviews™ in Neurobiology

ISSN 印刷: 0892-0915
ISSN オンライン: 2375-0014

Archives: Volume 10, 1996 to Volume 20, 2008

Critical Reviews™ in Neurobiology

DOI: 10.1615/CritRevNeurobiol.v15.i1.10
40 pages

Autoimmunity in the Peripheral Nervous System

Angelo Quattrini
Neuropathology Unit, L24, lotto Q, Dept. Neurology, San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milano, Italy
Stefano C. Previtali
Dept. of Neurology, San Raffaele Scientific Institute, Milano, Italy
Bernd C. Kieseier
Dept. of Neurology, Heinrich Heine Universitat, Dusseldorf, Germany
Reinhard Kiefer
Dept. of Neurology, Universitatsklinikum, Munster, Germany
Giancarlo Comi
Dept. of Neurology, San Raffaele Scientific Institute, Milano, Italy
Hans-Peter Hartung
Dept. of Neurology, Heinrich Heine Universitat, Dusseldorf, Germany

要約

Autoimmune disorders of the peripheral nervous system (PNS) comprise a heterogeneous group of diseases that result from an aberrant immune response. Most of these disorders present severe morbidity and, in some cases, mortality. Even those conditions that are self-limited may display severe disability and necessitate hospitalization. Although their etiology remains elusive, there is increasing knowledge of the pathophysiological mechanisms causing tissue dysfunction and structural damage. The discovery of several mediators that constitute the molecular mechanisms of cell-cell and cell-extracellular-matrix interactions has revealed insight into various aspects of the neuroimmune interaction. Classic animal models associated with new genetic approaches have further increased our comprehension of the molecular pathways that regulate inflammatory disorders of the nervous system. The aim of this review is to describe various types and functions of the principal molecular components of the neuroimmune interaction and their importance in the principal autoimmune disorders of the PNS. We also provide an extensive description of clinical and pathological features of autoimmune disorders of the PNS, along with diagnostic and therapeutic implications.


Articles with similar content:

The Ambivalent Nature of T-Cell Infiltration in the Central Nervous System of Patients with Multiple Sclerosis
Critical Reviews™ in Immunology, Vol.27, 2007, issue 1
Jerome J. A. Hendriks, Joris Vanderlocht, Piet Stinissen, Niels Hellings
Immunometabolic Signaling Pathways Contribute to Macrophage and Dendritic Cell Function
Critical Reviews™ in Immunology, Vol.36, 2016, issue 5
Aditya P. Dandekar, Lucas T. Jennelle, Tshifhiwa Magoro, Young S. Hahn
Role of NF-κB in Neurodegenerative Diseases
Forum on Immunopathological Diseases and Therapeutics, Vol.4, 2013, issue 2
Ronny Haenold, Alexandra Kretz, Falk Weih
Insulin-Like Growth Factor 1 in Cerebrovascular Pathology
International Journal of Physiology and Pathophysiology, Vol.8, 2017, issue 3
Olga Yu. Harmatina
Glucocorticoid-Induced Apoptosis in Animal Models of Multiple Sclerosis
Critical Reviews™ in Immunology, Vol.33, 2013, issue 3
Marco J. Herold, Holger Reichardt