RT Journal Article ID 05b0ea6a37554814 A1 Chadha, Renu A1 Saini, Anupam A1 Arora, Poonam A1 Bhandari, Swati T1 Pharmaceutical Cocrystals: A Novel Approach for Oral Bioavailability Enhancement of Drugs JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2012 FD 2012-05-09 VO 29 IS 3 SP 183 OP 218 K1 cocrystals K1 solid state forms K1 solubility K1 dissolution K1 pharmacokinetic studies K1 bioavailability AB Solid dosage forms are by far the preferred drug delivery systems. However, these often face the problem of poor and erratic bioavailability during the drug development process. Numerous formulation strategies for drug delivery are currently under development, among which the solid forms such as polymorphs, solvates, salts, and cocrystals have been considered to be the most important for improving dissolution rate and bioavailability. Cocrystallization is a fairly new approach in pharmaceutical industry that can improve the solubility and, consequently, the bioactivity of the active pharmaceutical ingredient (API) without compromising its structural integrity. Pharmaceutical cocrystals have found their place in drug delivery, primarily due to their ability to produce alternative, viable solid forms when a more standard approach of salt and polymorph formation fails to deliver the desired objectives. Over the past few years, a number of papers have been published focusing on a broad range of subjects, from traditional crystal engineering to structure-property relationships of cocrystals. The present review, however, illustrates how the cocrystalline forms of APIs have improved their in vitro dissolution rate and in vivo bioavailability, often correlating well with their improved solubility as well. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,6c024a1f2dc67178,05b0ea6a37554814.html