RT Journal Article
ID 0bbadf897de2d53c
A1 Miyagawa, Ippei
A1 Nakayamada, Shingo
A1 Kondo, Masahiro
A1 Tanaka, Yoshiya
T1 Regulatory Mechanism of The Induction of Regulatory T Cells through Growth Factors Released by Human Mesenchymal Stem Cells
JF Critical Reviews™ in Immunology
JO CRI
YR 2018
FD 2018-11-29
VO 38
IS 6
SP 471
OP 478
K1 human mesenchymal stem cells
K1 regulatory T cells
K1 growth factor
K1 insulin-like growth factor
AB Mesenchymal stem cells (MSCs) undergo self-renewal and differentiation into multiple lineages. They exert anti-inflammatory and immunomodulatory effects via either cell–cell contact or via the production of soluble factors.
Various anti-inflammatory and immunomodulatory mechanisms have been identified using experimental murine MSCs. The most representative mechanism is the induction of FOXP3+ regulatory T cells (Treg cells) via the production of transforming growth factor (TGF)-β, which has also been reported in human MSCs. Recent studies have demonstrated that insulin-like growth factor (IGF) is also involved in the induction of FOXP3+ Treg cells. We previously demonstrated that the induction of FOXP3+ Treg cells by IGF is suppressed by the expression of IGF-binding protein-4 (IGFBP-4), which is an inhibitor of IGF. Because human MSCs produce both IGFs and IGFBP4, they may be considered to maintain immunological homeostasis by positive regulation of Treg cells through the production of growth factors as well as by a negative regulatory mechanism. Although human MSCs have already been applied in regenerative therapy and autoimmune disease treatment, control of their positive and negative regulatory mechanisms is expected to lead to more efficient clinical applications.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,50bd6b32256cb3e1,0bbadf897de2d53c.html