RT Journal Article
ID 0ddd6f5679611304
A1 Benvegnu, Dalila
A1 Barcelos, Raquel C. S.
A1 Roversi, Katiane
A1 Boufleur, N.
A1 Pase, Camila S.
A1 Trevizol, Fabiola
A1 Segat, Hecson J.
A1 Dias, Veronica T.
A1 Dolci, Geisa S.
A1 Antoniazzi, Caren T. D.
A1 Reckziegel, Patricia
A1 Lima, Fernanda
A1 de Lima, Luiz André
A1 de Carvalho, Leandro M.
A1 da Silva Junior, Valdemiro A.
A1 Burger, M.E.
T1 Aqueous Extract of Pecan Nut Shell (Carya illinoensis [Wangenh.] K. Koch) Exerts Protection Against Oxidative Damage Induced by Cyclophosphamide in Rat Testis
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2013
FD 2013-12-12
VO 32
IS 4
SP 329
OP 341
K1 cyclophosphamide
K1 Carya illinoensis
K1 pecan nut shells
K1 oxidative stress
K1 antioxidant
K1 testis
AB This study investigated the protective effect of pecan nut (Carya illinoensis) shell aqueous extract (AE)
on the oxidative and morphological status of rat testis treated with cyclophosphamide (CP). Wistar rats received
water or AE (5%) ad libitum for 37 days. On day 30, half of each group received a single intraperitoneal administration of vehicle or CP 200 mg/kg. After 7 days, the animals were killed and their testis removed. Rats treated with CP presented reduced levels of lactate dehydrogenase, vitamin C, and gluthatione, as well as decreased catalase activity, increased lipid peroxidation levels and superoxide dismutase activity, no alteration in carbonyl protein levels, and a loss of morphological testicular integrity. In contrast, cotreatment with pecan shell AE totally prevented the decrease of lactate dehydrogenase and vitamin C levels and catalase activity and partially prevented the depletion of gluthatione levels. Moreover, it totally prevented the increase in superoxide dismutase activity and lipid peroxidation levels and maintained testicular integrity. These findings show the protective role of pecan shell AE in CP-induced testicular toxicity. The use of this phytotherapy may be considered to minimize deleterious effects related to this chemotherapy.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,2ffa0c0e097f11c3,0ddd6f5679611304.html