RT Journal Article ID 0ddd6f5679611304 A1 Benvegnu, Dalila A1 Barcelos, Raquel C. S. A1 Roversi, Katiane A1 Boufleur, N. A1 Pase, Camila S. A1 Trevizol, Fabiola A1 Segat, Hecson J. A1 Dias, Veronica T. A1 Dolci, Geisa S. A1 Antoniazzi, Caren T. D. A1 Reckziegel, Patricia A1 Lima, Fernanda A1 de Lima, Luiz André A1 de Carvalho, Leandro M. A1 da Silva Junior, Valdemiro A. A1 Burger, M.E. T1 Aqueous Extract of Pecan Nut Shell (Carya illinoensis [Wangenh.] K. Koch) Exerts Protection Against Oxidative Damage Induced by Cyclophosphamide in Rat Testis JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2013 FD 2013-12-12 VO 32 IS 4 SP 329 OP 341 K1 cyclophosphamide K1 Carya illinoensis K1 pecan nut shells K1 oxidative stress K1 antioxidant K1 testis AB This study investigated the protective effect of pecan nut (Carya illinoensis) shell aqueous extract (AE) on the oxidative and morphological status of rat testis treated with cyclophosphamide (CP). Wistar rats received water or AE (5%) ad libitum for 37 days. On day 30, half of each group received a single intraperitoneal administration of vehicle or CP 200 mg/kg. After 7 days, the animals were killed and their testis removed. Rats treated with CP presented reduced levels of lactate dehydrogenase, vitamin C, and gluthatione, as well as decreased catalase activity, increased lipid peroxidation levels and superoxide dismutase activity, no alteration in carbonyl protein levels, and a loss of morphological testicular integrity. In contrast, cotreatment with pecan shell AE totally prevented the decrease of lactate dehydrogenase and vitamin C levels and catalase activity and partially prevented the depletion of gluthatione levels. Moreover, it totally prevented the increase in superoxide dismutase activity and lipid peroxidation levels and maintained testicular integrity. These findings show the protective role of pecan shell AE in CP-induced testicular toxicity. The use of this phytotherapy may be considered to minimize deleterious effects related to this chemotherapy. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,2ffa0c0e097f11c3,0ddd6f5679611304.html