RT Journal Article ID 29c1f0412855e47f A1 Yi, Yun-Bo T1 STOCHASTIC MODELING OF MACROMOLECULAR MOTIONS THROUGH POST ARRAYS JF International Journal for Multiscale Computational Engineering JO JMC YR 2013 FD 2013-06-11 VO 11 IS 4 SP 347 OP 358 K1 macromolecules K1 post arrays K1 stochastic modeling K1 finite element analysis AB The dynamic motions of macromolecules through a microfluidic postarray system are simulated using a three-dimensional stochastic finite element approach. The effects of molecular conformation on the time for a macromolecule to move across the system are investigated. The analyses are first performed on disklike geometries and then extended to a representative carbonic anhydrase (CA) macromolecule model consisting of elastically deformable beam networks. The model predicts that smaller molecules typically take less time to pass through the post array, and that for stiff materials the time inversely increases with the aspect ratio of molecules due to the conformational changes in collisions between the molecules and the obstacles. In addition, the dynamic responses of molecules are highly stochastic. The work has potential applications in designing functional microfluidic devices for separation and purification of macromolecules such as plasmid DNA. PB Begell House LK https://www.dl.begellhouse.com/journals/61fd1b191cf7e96f,0166231359bf4331,29c1f0412855e47f.html