RT Journal Article ID 2d210ba20ba4a6c5 A1 Aktug, Hüseyin A1 Ozdil, Berrin A1 Kocatürk, Duygu Calik A1 Acikgoz, Eda T1 Holistic Approach to Cell Characteristics and Behavioral Analysis JF Critical Reviews™ in Oncogenesis JO CRO YR 2019 FD 2019-01-18 VO 24 IS 1 SP 21 OP 26 K1 cell behavior K1 cancer cell K1 cytoskeleton K1 embryonic stem cell K1 cell cycle AB Cancer is a group of diseases of our era that affects not only medical status but also lowers the tone of social and emotional well-being. It also has severe impacts on economies. Cancer cells are linked to the somatic cells and stem cells, with their characteristic similarities and differences. Variations in cell-signaling pathways, such as cell death and proliferation balances, kinetic behavior of the cells, and their differentiation potentials, are the featured parameters for therapeutic targeting. The detection of target points should be based not only on the molecular biology methods but also on the physical and topological analyses from the aspect of "geography is fate". In this review, we focus on the importance of the holistic analyses of intracellular and extracellular dynamics and multidisciplinary cooperation. PB Begell House LK https://www.dl.begellhouse.com/journals/439f422d0783386a,370a5a2d6539c279,2d210ba20ba4a6c5.html