RT Journal Article
ID 319dfb01276d3ad1
A1 Erkekoglu, Pinar
A1 Oral, Didem
A1 Kocer-Gumusel, Belmar
A1 Chao, Ming-Wei
T1 DNA Double-Strand Breaks Caused by Different Microorganisms: A Special Focus on Helicobacter pylori
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2017
FD 2017-06-20
VO 36
IS 2
SP 131
OP 150
K1 DNA damage
K1 double-strand DNA break
K1 gastric cancer
K1 Helicobacter pylori
K1 inflammation
K1 reactive oxygen species
AB The association between inflammation and cancer has long been recognized. Several studies have found that different types of tumors develop at sites of chronic inflammation. It is stated that over 15%−20% of malignancies worldwide can be related to infections caused by viruses, bacteria, and schistosomes. Inflammatory conditions are characterized by overexpression of inducible nitric oxide synthase (iNOS) and overproduction of nitric oxide/reactive nitrogen species (ROSs/RNSs) in epithelial cells. Reactive oxygen species (ROSs) may also lead to cellular alterations and eventually to inflammation. A variety of chronic infectious diseases can generate steady-state levels of ROSs/RNSs within infected cells and possibly lead to different types of DNA lesions. Accumulation of DNA lesions may finally lead to mutations that may activate oncogenes or inactivate tumor suppressor genes. Helicobacter pylori has been shown to generate ROSs/RNSs, induce DNA damage, and lead to chronic inflammation in gastric epithelial cells. A limited number of studies have addressed the effects of Helicobacter pylori on DNA damage, particularly its impact on single-strand and double-strand DNA breaks. This bacterium is classified as a Group I carcinogen by the International Agency for Research on Cancer on the basis of numerous animal and epidemiological studies. Chronic Helicobacter pylori infection can lead to increased risk of gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma. This review addresses the DNA-damaging and double-strand break-inducing effects of different microorganisms and their toxins, specifically focusing on Helicobacter pylori.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,07051ad6449b2804,319dfb01276d3ad1.html