RT Journal Article ID 31e90f611b83aea5 A1 Joslin, Jessica M. A1 McCall, James R. A1 Bzdek, Justin P. A1 Johnson, Derek C. A1 Hybertson, Brooks M. T1 Aqueous Plasma Pharmacy: Preparation Methods, Chemistry, and Therapeutic Applications JF Plasma Medicine JO PMED YR 2016 FD 2017-01-12 VO 6 IS 2 SP 135 OP 177 K1 plasma pharmacy K1 aqueous plasma pharmacy K1 plasma medicine K1 plasma-activated medium K1 plasma-stimulated medium K1 plasma-activated solution AB Plasma pharmacy is a subset of the broader field of plasma medicine. Although not strictly defined, the term aqueous plasma pharmacy (APP) is used to refer to the generation and distribution of reactive plasma-generated species in an aqueous solution followed by subsequent administration for therapeutic benefits. APP attempts to harness the therapeutic effects of plasma-generated oxidant species within aqueous solution in various applications, such as disinfectant solutions, cell proliferation related to wound healing, and cancer treatment. The subsequent use of plasma-generated solutions in the APP approach facilitates the delivery of reactive plasma species to internal locations within the body. Although significant efforts in the field of plasma medicine have concentrated on employing direct plasma plume exposure to cells or tissues, here we focus specifically on plasma discharge in aqueous solution to render the solution biologically active for subsequent application. Methods of plasma discharge in solution are reviewed, along with aqueous plasma chemistry and the applications for APP. The future of the field also is discussed regarding necessary research efforts that will enable commercialization for clinical deployment. PB Begell House LK https://www.dl.begellhouse.com/journals/5a5b4a3d419387fb,2cd4f93b5efd4449,31e90f611b83aea5.html