RT Journal Article ID 454373772cb11bdb A1 Kavdia, Mahendra A1 Tsoukias, Nikolaos M. T1 Preface JF Critical Reviews™ in Biomedical Engineering JO CRB YR 2011 FD 2011-12-22 VO 39 IS 5 SP 361 OP 362 K1 Cardiovascular disease K1 arrhythmia K1 nitric oxide K1 calcium K1 superoxide K1 peroxynitrite K1 hydrogen peroxide K1 superoxide dismutase K1 tyrosine nitration K1 endothelial cell K1 microcirculation K1 biotransport K1 biophysical K1 kinetics K1 ATP K1 mitochondria K1 endothelial cell AB This issue of Journal of Critical Reviews in Biomedical Engineering contains five review articles on the current state and contribution of modeling of signal transduction at different scales in cardiovascular systems. These review papers address diverse issues such as oxidative and nitrosative stress, electrophysiology, cell signaling and metabolism, the regulation of local perfusion and oxygenation, several signaling pathways in the microcirculation that involve NO, and calcium and mitochondrial energy transduction. They highlight the contribution of computational modeling to our understanding of cardiovascular systems from molecules to whole organ and in physiology and pathophysiology and therapeutic approaches. The reviews provide a reader the comprehensive view of challenges and opportunities in modeling in cardiovascular systems. PB Begell House LK https://www.dl.begellhouse.com/journals/4b27cbfc562e21b8,4513fb4953b8ab42,454373772cb11bdb.html