RT Journal Article ID 45bec69c02d9c6ce A1 Deitiker, Philip A1 Atassi, M. Zouhair T1 Non-MHC Genes Linked to Autoimmune Disease JF Critical Reviews™ in Immunology JO CRI YR 2012 FD 2012-11-16 VO 32 IS 3 SP 193 OP 285 K1 Autoimmune diseases K1 chromosomes K1 genetic markers K1 non-MHC genes K1 risk factors K1 haplotypes K1 genetic risk AB The genetic traits that result in autoimmune diseases represent complicating factors in explicating the molecular and cellular elements of autoimmune responses and how these responses can be overcome or manipulated. This article focuses on the major non-major histocompatibility complex genes that have been found to be linked to autoimmune diseases. A given gene may associate with a number of autoimmune diseases and, conversely, a given disease may link to a number of common autoimmune disease (AD) genes. Collaboration and interaction among genes and the number of diseases that develop and the extensive risk factors shared among ADs further complicate the outcome. This article describes the various relationships between gene regions associated with multiple ADs and the complexity of those relationships. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,6186cede575ddcdf,45bec69c02d9c6ce.html