RT Journal Article
ID 46a9844d18549d7c
A1 Nakagawa, Ikuma 
A1 Kamimura, Daisuke 
A1 Atsumi, Toru 
A1 Arima, Yasunobu 
A1 Murakami, Masaaki
T1 Role of Inflammation Amplifier-Induced Growth Factor Expression in the Development of  Inflammatory Diseases
JF Critical Reviews™ in Immunology
JO CRI
YR 2015
FD 2016-01-29
VO 35
IS 5
SP 365
OP 378
K1 Inflammation amplifier
K1 interleukin-6
K1 interleukin-17
K1 nuclear factor-kappa B
K1 signal transducers and
 activator of transcription 3
K1 growth factor
AB Inflammation is a fundamental response induced by the immune system to protect the body against pathogens, tissue damage, and stress. At the same time, recent studies have suggested that chronically induced inflammation is involved in various human diseases and disorders. Thus, understanding the molecular mechanisms of chronic inflammation could provide therapeutic value. Many mediators such as cytokines or chemokines regulate
inflammatory responses. Among them, interleukin(IL)-6 is a prominent cytokine that induces and maintains inflammatory
reactions. It is expressed by activated CD4+ T cells and also non-immune cells such as fibroblasts and epithelial
cells. We discovered an inflammation-induction machinery, the inflammation amplifier, which is activated by the
simultaneous stimulation of nuclear factor-kappa B (NF-κB) and signal transducers and activator of transcription 3 (STAT3) via various cytokines like IL-17 and IL-6 in non-immune cells. Activation of the inflammation amplifier induces a synergistic increase of IL-6, inflammatory chemokines, and growth factors. Using genome-wide screening, we identified several growth factors as mediators of the inflammation amplifier. In this review, we highlight the role of growth factors in the inflammation mechanism with special attention on the inflammation amplifier.

PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,3cf9880e7437a8b5,46a9844d18549d7c.html