RT Journal Article ID 49b05c26344914ea A1 McGavern, Dorian B. T1 The Role of Bystander T Cells in CNS Pathology and Pathogen Clearance JF Critical Reviews™ in Immunology JO CRI YR 2005 FD 2005-08-17 VO 25 IS 4 SP 289 OP 304 AB It is generally accepted that both self- and pathogen-specific T lymphocytes have the potential to mediate immunopathogenesis and contribute to a variety of human ailments. Despite this unfortunate tendency to induce tissue injury, these cells are guided by interactions with peptide-loaded major histocompatibility complexes (MHC) and adhere appropriately to a vital evolutionary constraint imposed by the host: specificity. More recently, a series of studies have demonstrated that bystander T cells of an irrelevant specificity can bypass peptide/MHC restriction and become active participants in immunopathology. This review critically evaluates the role of bystander T cells in immunopathogenesis and pathogen clearance in the periphery as well as the central nervous system and attempts to establish the likelihood of their participation in human disease. PB Begell House LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,142efedf22ac8fe3,49b05c26344914ea.html