RT Journal Article ID 509311d8290fb0d9 A1 Gupta, Preeti A1 Garg, Tarun A1 Tanmay, M. A1 Arora , Saahil T1 Polymeric Drug-Delivery Systems: Role in P-gp Efflux System Inhibition JF Critical Reviews™ in Therapeutic Drug Carrier Systems JO CRT YR 2015 FD 2015-05-08 VO 32 IS 3 SP 247 OP 275 K1 polymeric drug delivery K1 multidrug resistance K1 chemotherapy K1 ABC transporter K1 P-gp efflux pump modulators AB Permeability glycoprotein (P-gp), a multispecific drug transporter belonging to the multidrug resistance (MDR) gene subfamily, is mainly responsible for efflux of diffused intracellular drugs, resulting in poor drug bioavailability. P-gp is overexpressed in the blood-brain barrier, gastrointestinal tract (GIT), kidney, liver, pancreas, and cancerous cells, leading to multidrug resistance and failure of therapy. Because P-gp is transported into cells by way of receptor-mediated endocytosis (in contrast to diffusion for free drug), polymeric efflux pump modulators can have a major role in efficient drug delivery. Various polymer drug conjugates that have been proven to provide potential treatments in MDR cases are reviewed here, with an emphasis on the role of the P-gp efflux pump, bioavailability, and the mechanism of inhibition of the P-gp transporter by various polymers and delivery systems. This review also highlights the potential of specific polymer drug conjugates to act as P-gp efflux pump inhibitors to provide enhanced bioavailability and therapeutic efficacy. PB Begell House LK https://www.dl.begellhouse.com/journals/3667c4ae6e8fd136,4ee499aa7c16e67a,509311d8290fb0d9.html