RT Journal Article ID 50f005142b10c363 A1 Rozova, Kateryna V. T1 Effect of Different Origin Hypoxia on the Status of the Cyclic Nucleotide System and on the Morphofunctional Changes in the Lung and in the Heart Tissues JF International Journal of Physiology and Pathophysiology JO IJPP YR 2011 FD 2011-03-01 VO 2 IS 1 SP 25 OP 33 K1 cyclic nucleotides K1 morphofunctional status K1 hypoxic hypoxia K1 acute blood loss K1 immobilization stress K1 LP K1 adenylate cyclase AB We have investigated the intercommunication of the functional state of cyclic nucleotides (CN) system and morphofunctional states of lung and heart tissues and influence on these states of lipid peroxidation processes and adenylate cyclase system activity under development in organism of the hypoxic states of different genesis. Obtained dates testify that with the changes of cAMP and cGMP concentrations, and also with their ratio the level of hyperhydratation of air-blood and blood-tissue barriers under the used influence on the organism are closely correlated. Intercommunication of the cyclic nucleotides system functioning and tissues oxygen consumption at the used influences carries sufficiently difficult and ambiguous character. It was shown that exactly at blood loss in lung and heart tissues there were the parallel diminishing of concentrations both cAMP and cGMP. It is accepted to correlate with a favorable histological dynamics. Exactly under these conditions the correlation of CN concentrations is possible to consider balanced and sent to limitation of displays of unfavorable influence of blood loss on investigated tissues ultrastructure. So, there is a tissue specific and depending from the type of influence on the organism character of intercommunication of the functional state of cyclic nucleotides system and morphofunctional states of lung and heart tissues. PB Begell House LK https://www.dl.begellhouse.com/journals/6ec4ba27650016b1,4233e80d10b9a4d1,50f005142b10c363.html