RT Journal Article ID 51bfd2bb03dae71d A1 Das, Avratanu A1 Roy, Amrita A1 Das, Ruma A1 Bhattacharya, Sanjib A1 Haldar, Pallab Kanti T1 Naringenin Alleviates Cadmium-Induced Toxicity through the Abrogation of Oxidative Stress in Swiss Albino Mice JF Journal of Environmental Pathology, Toxicology and Oncology JO JEP(T) YR 2016 FD 2016-07-28 VO 35 IS 2 SP 161 OP 169 K1 cadmium K1 toxicity K1 naringenin K1 oxidative stress K1 flavonoid AB The present study evaluates the protective potential of the flavonoid naringenin (NRG) against experimentally induced cadmium (Cd) toxicity in Swiss albino mice. NRG (4 and 8 mg/kg) was orally administered to mice 30 min before oral administration of CdCl2 (12 mg/kg) for 11 consecutive days. On the 12th day, we evaluated body and organ weights, hematological profiles, serum biochemical profiles, and hepatic and renal tissue antioxidative parameters including lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, and catalase. Cotreatment with NRG markedly and significantly normalized body and organ weights, hematological profiles, and serum biochemical profiles and significantly modulated all of the hepatic and renal tissue biochemical parameters in Cd-intoxicated mice. The present findings show that NRG possesses a remarkable alleviative effect against Cd-induced toxicity in albino mice, mediated by abrogation of Cd-induced oxidative stress by multiple mechanisms. PB Begell House LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,1618a93b7a136570,51bfd2bb03dae71d.html