RT Journal Article
ID 51bfd2bb03dae71d
A1 Das, Avratanu
A1 Roy, Amrita
A1 Das, Ruma
A1 Bhattacharya, Sanjib
A1 Haldar, Pallab Kanti
T1 Naringenin Alleviates Cadmium-Induced Toxicity through the Abrogation of Oxidative Stress in Swiss Albino Mice
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2016
FD 2016-07-28
VO 35
IS 2
SP 161
OP 169
K1 cadmium
K1 toxicity
K1 naringenin
K1 oxidative stress
K1 flavonoid
AB The present study evaluates the protective potential of the flavonoid naringenin (NRG) against experimentally induced cadmium (Cd) toxicity in Swiss albino mice. NRG (4 and 8 mg/kg) was orally administered to mice 30 min before oral administration of CdCl2 (12 mg/kg) for 11 consecutive days. On the 12th day, we evaluated body and organ weights, hematological profiles, serum biochemical profiles, and hepatic and renal tissue antioxidative parameters including lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, and catalase. Cotreatment with NRG markedly and significantly normalized body and organ weights, hematological profiles, and serum biochemical profiles and significantly modulated all of the hepatic and renal tissue biochemical parameters in Cd-intoxicated mice. The present findings show that NRG possesses a remarkable alleviative effect against Cd-induced toxicity in albino mice, mediated by abrogation of Cd-induced oxidative stress by multiple mechanisms.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,1618a93b7a136570,51bfd2bb03dae71d.html