RT Journal Article ID 56b24ee77f8627e6 A1 Rodriguez-Ramirez, Christie A1 Nör, Jacques E. T1 p53 and Cell Fate: Sensitizing Head and Neck Cancer Stem Cells to Chemotherapy JF Critical Reviews™ in Oncogenesis JO CRO YR 2018 FD 2018-09-04 VO 23 IS 3-4 SP 173 OP 187 K1 head and neck cancer K1 p53 K1 cancer stem cells K1 differentiation K1 self-renewal AB Head and neck cancers are deadly diseases that are diagnosed annually in approximately half a million individuals worldwide. Growing evidence supporting a role for cancer stem cells (CSCs) in the pathobiology of head and neck cancers has led to increasing interest in identifying therapeutics to target these cells. Apart from the canonical tumor-suppressor functions of p53, emerging research supports a significant role for this protein in physiological stem cell and CSC maintenance and reprogramming. Therefore, p53 has become a promising target to sensitize head and neck CSCs to chemotherapy. In this review, we highlight the role of p53 in stem cell maintenance and discuss potential implications of targeting p53 to treat patients with head and neck cancers. PB Begell House LK https://www.dl.begellhouse.com/journals/439f422d0783386a,514990c96a5e2eab,56b24ee77f8627e6.html