RT Journal Article
ID 57cf9d437e8146a5
A1 Haldar, Sagnik
A1 Karmakar, Indrajit
A1 Chakraborty, Mainak
A1 Ahmad, Dilshad
A1 Haldar, Pallab Kanti
T1 Antitumor Potential of Thevetia peruviana on Ehrlich's Ascites Carcinoma−Bearing Mice
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2015
FD 2015-02-27
VO 34
IS 2
SP 105
OP 113
K1 Thevetia peruviana
K1 Apocynaceae
K1 EAC cell line
K1 antitumor activity
K1 5-fluorouracil
AB Methanol extracts of Thevetia peruviana (METP) (Apocynaceae) fruit showed antitumor activity against
Ehrlich's ascites carcinoma (EAC) cell line in Swiss albino mice. The METP-treated group's tumor volume, tumor
weight, and viable cell count were decreased compared to the EAC control group. Tumor volumes were 3.62±0.12
ml, 2.88±0.23 ml, and 1.34±0.17 ml for the EAC control group and the METP-treated groups (50 mg/kg and 100
mg/kg body weight), respectively. Nonviable cell counts were 4.44%±0.42%, 18.57%±3.07%, and 68.12%±5.32% in the EAC control group and the METP-treated groups (50 mg/kg and 100 mg/kg body weight), respectively. METP-treated EAC cell-bearing mice had an increased life span (48.69% and 83.78%) compared to the EAC control group.
Hematological and serum biochemical profiles were restored to normal levels in METP-treated mice compared to the
EAC control group. METP significantly (P<0.001) decreased lipid peroxidation and recovered reduced glutathione, superoxide dismutase, and catalase toward normal levels compared to the EAC control group. In summary, METP exhibited remarkable antitumor activity in Swiss albino mice, which is plausibly attributable to its augmentation of endogenous antioxidant mechanisms.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,0972237e0d0d4968,57cf9d437e8146a5.html