RT Journal Article
ID 58e1981e1ca19ee5
A1 Schroeder, Sven
A1 Meyer-Hamme, Gesa
A1 Friedemann, Thomas
T1 Treatment of Chemotherapy Induced Peripheral Neuropathy: The Role of Medicinal Herbs
JF Onco Therapeutics
JO OT
YR 2012
FD 2012-04-25
VO 3
IS 1
SP 15
OP 39
K1 Polyneuropathy
K1 traditional Chinese medicine
K1 Chinese herbs
K1 chemotherapy-induced neuropathy
K1 Chinese medicine
K1 natural products
K1 medical plants
K1 antioxidative stress
K1 mitochondrial dysfunction
AB Chemotherapy-induced neuropathy (CIPN) is one main dose-limiting toxicity in oncologic treatment. It leads to neuropathic pain and gait impairment and decreases patients' quality of life. Platinum compounds such as taxanes, epothilones, vinca-alkaloids, bortezomib, and taladomide, are the major substances that cause CIPN. Presently, there are no curative conventional treatments for CIPN. Mechanisms of CIPN are not well known, but oxidative stress and mitochondrial dysfunction are involved. The aim of this review is to illuminate the possible role of herbal treatment in CIPN. Chamomile, Acorus calmus and Salvia officinalis show evidence of being effective against neuropathic pain, Gingko biloba and the herbal combination Goshajinkigan (Niu-che-sen-qi-wan) show some evidence of preventing neuronal degeneration in CIPN. Herbal antioxidants and herbs for enhancement of nerve growth as putative treatment options for CIPN are reviewed here. Many promising substances, mainly Chinese medicinal herbs with possible effects on CIPN or a putative influence on mechanisms of CIPN, have been identified in recent years, but no clear clinical recommendation for herbal treatment of CIPN can be provided by this review. Modern research on Chinese medical herbs should not only focus on single components but also on herbal combinations to develop treatments for multifactorial diseases like CIPN.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2c6306423483e001,5a91e1b46b84d3b2,58e1981e1ca19ee5.html