RT Journal Article ID 649dc7da64830b0a A1 Giannitrapani, Lydia A1 Multhoff, Gabriele T1 The Role of HSP70 in the Diagnosis of HCC JF Onco Therapeutics JO OT YR 2014 FD 2015-07-31 VO 5 IS 3-4 SP 137 OP 143 K1 Diagnosis of HCC K1 Hsp70 K1 liquid biopsy K1 tumor biomarker AB Hepatocellular carcinoma (HCC) is a common tumor with a fatal clinical outcome if not diagnosed at an early stage. To date there is still a lack of reliable tumor biomarkers to detect asymptomatic precursor lesions in early HCC. Conventional pathological analysis also often fails to achieve sufficient sensitivity and specificity to diagnose early HCC. Genetic, proteomic, immunohistochemical, and liquid biopsy analysis indicate a role for members of the heat-shock protein 70 (HSP70) family as potential tumor-specific markers for HCC. The aim of this review is to revisit the existing literature and to specifically explore HSP70 as a molecular tumor biomarker for the detection of HCC and its potential use as a tumor-specific target for future anticancer therapies in HCC. PB Begell House LK https://www.dl.begellhouse.com/journals/2c6306423483e001,5749d30276266f6f,649dc7da64830b0a.html