RT Journal Article
ID 66f6279e74d97ab5
A1 Jindal, Archana
A1 Agrawal, Annapurna
A1 Goyal, Pradeep Kumar
T1 Influence of Rosemarinus officinalis Extract on Radiation-Induced Intestinal Injury in Mice
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2010
FD 2011-01-07
VO 29
IS 3
SP 169
OP 179
K1 Gamma radiation
K1 Rosemarinus officinalis
K1 Glutathione
K1 Lipid Peroxidation
K1 Swiss albino mice
K1 Chemical Protection
AB The radioprotective effect of Rosemarinus officinalis extract (ROE) was studied in mice exposed to 3 Gy gamma radiation. Crypt survival, villus length, apoptotic cells, mitotic figures and goblet cells in intestine were studied at different autopsy intervals i.e. 12 hrs to 30 days after irradiation. Maximum changes in all the intestinal parameters were observed on day 3 after irradiation. Irradiated animals with ROE pretreatment exhibited a significant increase in the number of crypt cells, mitotic figures and villus length; whereas a significant decrease in the counts of apoptotic and goblet cells showed a significant decrease respective controls at all the autopsy intervals. Irradiation of animals resulted an elevation in lipid peroxidation and a reduction in glutathione concentration in the intestine at 1 hour post-irradiation. In contrast, ROE treatment before irradiation caused a significant depletion in lipid peroxidation and elevation
in glutathione levels.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,109099df1c668e76,66f6279e74d97ab5.html