RT Journal Article
ID 68070fad46191115
A1 Shathish, Kittappa
A1 Sakthivel , Kunnathur Murugesan
A1 Guruvayoorappan, Chandrasekaran
T1 Protective Effect of Solanum muricatum on Tumor Metastasis by Regulating Inflammatory Mediators and Nuclear Factor-Kappa B Subunits
JF Journal of Environmental Pathology, Toxicology and Oncology
JO JEP(T)
YR 2015
FD 2015-06-23
VO 34
IS 3
SP 249
OP 262
K1 metastasis; Solanum muricatum; TNF-α
K1 iNOS
K1 NF-κB
AB Metastasis is one of the hallmarks of malignant neoplasm or cancer, which is the leading cause of death in many cancer patients. A major challenge in cancer treatment is to find better ways to specifically target tumor metastases. In this study, the anti-metastatic potential of the methanol extract of Solanum muricatum (S. muricatum)
was evaluated using B16F-10 melanoma cell−induced lung metastasis in C57BL/6 mice. Treatment with
S. muricatum significantly inhibited the lung tumor nodule formation and reduced the lung collagen hydroxyproline, hexosamine, and uronic acid levels (p<0.01). Similarly, serum sialic acid and γ-glutamyl transpeptidase levels were also significantly inhibited after S. muricatum treatment. The levels of proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, granulocyte monocyte colony-stimulating factor (GM-CSF), and IL-2 in serum were significantly regulated after treatment with S. muricatum. The serum nitric oxide level was also decreased significantly and was accompanied by a decrease in inducible nitric oxide synthase (iNOS) and cyclo-
oxygenase (COX)-2 expressions after S. muricatum treatment. The present study reveals that S. muricatum treatment was able to alter the proinflammatory cytokine production as well as inhibit the activation and nuclear translocation of nuclear factor-κB (p65 and p50) subunits.
PB Begell House
LK https://www.dl.begellhouse.com/journals/0ff459a57a4c08d0,5e769fe6726f83d4,68070fad46191115.html