RT Journal Article
ID 68cdbd6a4db5a0fc
A1 Ndhlovu, Lishomwa C.
A1 Takeda, Ikuo
A1 Sugamura, Kazuo
A1 Ishii, Naoto
T1 Expanding Role of T-Cell Costimulators in Regulatory T-Cell Function: Recent Advances in Accessory Molecules Expressed on Both Regulatory and Nonregulatory T Cells
JF Critical Reviews™ in Immunology
JO CRI
YR 2004
FD 2004-11-04
VO 24
IS 4
OP 16
AB A subpopulation of T cells harbors a suppressor phenotype and can significantly dampen autoreactive CD4<sup>+</sup> and CD8<sup>+</sup> T-cell responses. These regulatory T (Treg) cells, which can arise naturally in the thymus and encompass a CD25<sup>+</sup>CD4<sup>+</sup> T-cell repertoire or be antigenically induced, are central players in the maintenance of self-tolerance. A plethora of T-cell costimulatory and accessory receptor molecules expressed by Treg and/or non-regulatory T cells, such as GITR, OX40, and CTLA-4, are involved in modulating the pathogenesis of numerous autoimmune disorders, transplant rejection, and tumor immunity, as well as the control of infections. Exciting new evidence shows that T-cell costimulators, some of which are identified as hopeful discriminative Treg-cell markers, appear to mediate Treg-cell homeostasis and function. Understanding the biological significance of the T-cell costimulatory molecules and the accessory molecules expressed by Treg cells is a prerequisite to better characterizing this regulatory T-cell population. We provide a synopsis of the current understanding of several costimulatory molecules that can orchestrate the function of both naturally arising and antigen-inducible Treg cells.
PB Begell House
LK https://www.dl.begellhouse.com/journals/2ff21abf44b19838,10d2718a0313ad84,68cdbd6a4db5a0fc.html