RT Journal Article ID 6c7f73aa3d6b80bb A1 Teles, Ramon Handerson Gomes A1 Dutra, Yago Medeiros A1 do Vale, Donária Bezerra Nobre A1 dos Santos, Thiago Pereira A1 Neto, José Carlos Raposo Mazulo A1 de Brito, Tarcisio Vieira A1 Costa, Mariana de Souza A1 de Oliveira, Saul Barbosa A1 Brauna, Isabela de Souza A1 da Silva, Felipe Rodolfo Pereira A1 Filgueiras, Marcelo de Carvalho T1 Photobiomodulation in the Treatment of Muscle Injury: A Systematic Review JF Critical Reviews™ in Physical and Rehabilitation Medicine JO CRP YR 2018 FD 2018-03-02 VO 30 IS 1 SP 1 OP 14 K1 photobiomodulation K1 muscle injury K1 low-level laser AB Muscular injury is the loss of muscle function caused by damage of varying severity that compromises the structure and function of the affected segment and, in more severe cases, individuals and their daily tasks. Treatment is usually through the use of medicine, but in recent years, new therapies have been used to replace or reduce the use of drugs, which can cause side effects. Studies in animals allow more viable analysis than clinical studies. This study aimed to perform a systematic review of literature data on muscle inflammation in experimental models using animals treated with photobiomodulation. This review was conducted in concordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. A systematic literature search of studies performed before June 20, 2016, was conducted in the following databases: Cochrane Library, China DATABASE, Google Scholar, EMBASE, and PubMED. The extracted data were analyzed using Review Manager software (version 5.2). A total of 127 studies were found, of which eight were included in the final sample. Photobiomodulation effectiveness was observed on muscle regeneration, damage reduction, inflammatory process reduction, oxidative stress markers, and muscle fatigue; however, there was no significant association between inflammatory cell count and blood lactate levels. The results show effectiveness in the treatment of muscle injury; however, more studies are necessary to understand the influence of different parameters of irradiation equipment on biological processes. PB Begell House LK https://www.dl.begellhouse.com/journals/757fcb0219d89390,7cb4c199531a1452,6c7f73aa3d6b80bb.html