%0 Journal Article %A Jose, Nayana %A Ajith, Thekkuttuparambil Ananthanarayanan %A Janardhanan, Kainoor Krishnankutty %D 2002 %I Begell House %N 4 %P 7 %R 10.1615/IntJMedMushr.v4.i4.60 %T Antioxidant, Anti-inflammatory, and Antitumor Activities of Culinary-Medicinal Mushroom Pleurotus pufmonanus (Fr.) Quel. (Agaricomycetideae) %U https://www.dl.begellhouse.com/journals/708ae68d64b17c52,72e968661ff5d957,6e3d61ce400def1e.html %V 4 %X Antioxidant, antitumor, and anti-inflammatory activities of the methanol extract of Pleurotus pulmonarius (Fr.) Quel [= P. sajor-caju (Fr.) Singer] were evaluated. The methanol extract of P. pulmonarius showed significant hydroxyl radical-scavenging and lipid peroxidation-inhibiting activities; the concentrations required for 50% inhibition (IC50) were 476.67 and 960.0 mg/mL, respectively. However, the extract did not show superoxide radical-scavenging activity. The administration of the extract caused significant regression of solid tumor at concentrations of 250, 500, and 1000 mg/kg body weight. The extract was also significantly effective in reducing paw edema induced by carrageenan and formalin at concentrations of 500 and 1000 mg/kg body weight. In both the antitumor and anti-inflammatory models, the activity of the extracts was comparable to the standard reference drugs, cisplatin and diclofenac, respectively. The results thus suggest therapeutic potential for P. pulmonarius as an antitumor and anti-inflammatory agent. %8 2002-12-01