RT Journal Article
ID 7d276d0859679b62
A1 Vallano, Mary Lou
T1 Developmental Aspects of NMDA Receptor Function
JF Critical Reviews™ in Neurobiology
JO CRN
YR 1998
FD 1998-09-30
VO 12
IS 3
SP 177
OP 204
K1 neuron
K1 development
K1 migration
K1 survival
K1 glutamate receptors
K1 protein kinases
AB Glutamate is the major excitatory neurotransmitter in mammalian synapses. It binds to three classes of predominantly postsynaptic ionotropic receptors to activate receptor-associated channels, and a class of metabotropic receptors to activate G-protein mediated transduction pathways. The N-methyl-D-aspartate (NMDA) receptor (NR) is distinctive in being both ligand and voltage-gated, and selectively permeable to Ca2+. As a consequence, NR-mediated alterations in intracellular Ca2+ levels regulate a variety of signaling pathways, ranging from localized, acute effects on receptor and channel activities to long-term effects on nuclear gene transcription. Regulated expression, assembly, and modulation of distinct heteromeric NR complexes comprised of different subunit combinations contributes to this functional diversity. NRs have been implicated in several developmental processes, and evidence supporting their role in migration, survival, and synaptic maturation is discussed.
PB Begell House
LK https://www.dl.begellhouse.com/journals/7b004699754c9fe6,7ddb5c405a994f83,7d276d0859679b62.html