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Seventh International Symposium on Turbulence and Shear Flow Phenomena
July, 28-31, 2011, Ottawa Convention Centre, Ottawa, Canada

DOI: 10.1615/TSFP7

SIMULATIONS OF MAGNETIC CAPTURING EFFICIENCY OF DRUG CARRIERS IN THE BRAIN VASCULAR SYSTEM

pages 1-6
DOI: 10.1615/TSFP7.840
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要約

The present paper reports on numerical simulations of blood flow and magnetic drug carrier distributions in a complex brain vascular system. The blood is represented as a non-Newtonian fluid by generalised power law. The Lagrangian tracking of the multi-layer spherical particles is performed to estimate particle deposition under influence of imposed magnetic field gradients along arterial walls. Two situations are considered: neutral (magnetic field off) and active control (magnetic field on) case. The multi-layer spherical particles that mimic a real medical drug are characterised by two characteristic diameters - the outer one and the inner one of the magnetic core. A numerical mesh of the brain vascular system consisting of multi-branching arteries is generated from raw MRI scan images of a patient. The blood is supplied through fourmain inlet arteries and the entire vascular system included more than 30 outlets, which are modelled by Murray's law. The no-slip boundary condition is applied for velocity components along the smooth and rigid arterial walls. Numerical simulations revealed detailed insights into blood flow patterns, wall-shear-stress and local particle deposition efficiency along arterial walls. It is demonstrated that magnetically targeted drug delivery significantly increased the particle capturing efficiency in the pre-defined regions. This feature can be potentially useful for localised, non-invasive treatment of brain tumours.

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