Inscrição na biblioteca: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Luteolin Induces Cell Cycle Arrest and Apoptosis Through Extrinsic and Intrinsic Signaling Pathways in MCF-7 Breast Cancer Cells

Volume 33, Edição 3, 2014, pp. 219-231
DOI: 10.1615/JEnvironPatholToxicolOncol.2014010923
Get accessGet access

RESUMO

Luteolin is a common flavonoid that exists in medicinal herbs, fruits, and vegetables. Luteolin has biochemical functions including anti-allergy, anti-inflammation, and anti-cancer functions. However, its efficacy and precise mode of action against breast cancer are still under study. To elucidate whether luteolin exhibits an anticancer effect in breast cancer, MCF-7 breast cancer cells were incubated with luteolin, and apoptosis was assessed by observing nuclear morphological changes and by performing cell viability assay, cell cycle analysis, annexin V-FITC/PI double staining, western blotting, RT-PCR, and mitochondrial membrane potential measurements. Luteolin inhibited growth through perturbation of cell cycle progression at the sub-G1 and G1 phases in MCF-7 cells. Furthermore, luteolin enhanced the expression of death receptors, such as DR5, and activated caspase cascades. It enhanced the activities of caspase-8/-9/-3 in a dose-dependent manner, followed by inactivation of PARP. Activation of caspase-8 and caspase-9 induced caspase-3 activity, respectively, in apoptosis of extrinsic and intrinsic pathways. Luteolin also induced mitochondrial membrane potential collapse and cytochrome c release, and increased Bax expression by inhibiting expression of Bcl-2. Taken together, these results suggest that luteolin provokes cell cycle arrest and induces apoptosis by activating the extrinsic and intrinsic pathways.

CITADO POR
  1. Xu Huanli, Yang Tao, Liu Xiaohui, Tian Ye, Chen Xiaoliang, Yuan Ru, Su Shuonan, Lin Xiukun, Du Guanhua, Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism, Life Sciences, 144, 2016. Crossref

  2. Balyan Rajiv, Kudugunti Shashi K., Hamad Hamzah A., Yousef Mohammad S., Moridani Majid Y., Bioactivation of luteolin by tyrosinase selectively inhibits glutathione S-transferase, Chemico-Biological Interactions, 240, 2015. Crossref

  3. Makino Junya, Asai Rei, Hashimoto Mao, Kamiya Tetsuro, Hara Hirokazu, Ninomiya Masayuki, Koketsu Mamoru, Adachi Tetsuo, Suppression of EC-SOD by oxLDL During Vascular Smooth Muscle Cell Proliferation, Journal of Cellular Biochemistry, 117, 11, 2016. Crossref

  4. Yan Hongmei, Wei Pingping, Song Jie, Jia Xiaobin, Zhang Zhenhai, Enhanced anticancer activity in vitro and in vivo of luteolin incorporated into long-circulating micelles based on DSPE-PEG2000 and TPGS, Journal of Pharmacy and Pharmacology, 68, 10, 2016. Crossref

  5. Bak Min Ji, Das Gupta Soumyasri, Wahler Joseph, Suh Nanjoo, Role of dietary bioactive natural products in estrogen receptor-positive breast cancer, Seminars in Cancer Biology, 40-41, 2016. Crossref

  6. Lee Jae-Sung, Lim Ji-Na, Wang Tao, Lee Sang-Bum, Hwang Jin-Hee, Jung U-Suk, Kim Min-Jeong, Choi Seong-Ho, Ishizuka Satoshi, Lee Hong-Gu, Physiological concentrations of trans-11 18:1 vaccenic acid suppress pro-inflammatory markers under acute inflammation in isolated ICR mice splenocytes, Food Science and Biotechnology, 25, 1, 2016. Crossref

  7. Lee Hyuna, Kim Dae Shik, Ha Sang Keun, Choi Inwook, Lee Jong Min, Sung Jong Hwan, A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model, Biotechnology and Bioengineering, 114, 2, 2017. Crossref

  8. Köken Tülay, Koca Buğra, Özkurt Mete, Erkasap Nilüfer, Kuş Gökhan, Karalar Mustafa, Apium graveolensExtract Inhibits Cell Proliferation and Expression of Vascular Endothelial Growth Factor and Induces Apoptosis in the Human Prostatic Carcinoma Cell Line LNCaP, Journal of Medicinal Food, 19, 12, 2016. Crossref

  9. Raffa Demetrio, Maggio Benedetta, Raimondi Maria Valeria, Plescia Fabiana, Daidone Giuseppe, Recent discoveries of anticancer flavonoids, European Journal of Medicinal Chemistry, 142, 2017. Crossref

  10. Palko-Labuz Anna, Sroda-Pomianek Kamila, Uryga Anna, Kostrzewa-Suslow Edyta, Michalak Krystyna, Anticancer activity of baicalein and luteolin studied in colorectal adenocarcinoma LoVo cells and in drug-resistant LoVo/Dx cells, Biomedicine & Pharmacotherapy, 88, 2017. Crossref

  11. Alpsoy L., Baykal A., Akal Z. Ü., Luteolin-Loaded Spion as a Drug Carrier for Cancer Cell In Vitro, Journal of Superconductivity and Novel Magnetism, 31, 2, 2018. Crossref

  12. Deng Lan, Jiang Ling, Lin Xianghua, Tseng Kuo-Fu, Lu Zhigang, Wang Xiuju, Luteolin, a novel p90 ribosomal S6 kinase inhibitor, suppresses proliferation and migration in leukemia cells, Oncology Letters, 13, 3, 2017. Crossref

  13. Wang Shaokang, Fu Lingmeng, Wu Yi, Xiao Hongmei, Wang Jing, Sun Guiju, Influence of luteolin on the apoptosis of esophageal cancer Eca109 cells and its mechanism of action, Food Science and Human Wellness, 8, 2, 2019. Crossref

  14. Park Wonhyoung, Park Sunwoo, Song Gwonhwa, Lim Whasun, Inhibitory Effects of Osthole on Human Breast Cancer Cell Progression via Induction of Cell Cycle Arrest, Mitochondrial Dysfunction, and ER Stress, Nutrients, 11, 11, 2019. Crossref

  15. Kashyap Dharambir, Singh Tuli Hardeep, Yerer Mukerrem Betul, Sharma Anil K., Buttar Harpal Singh, Youns M., Sharifi-Rad Javad, Salehi Bahare, Setzer William N., Flavonoids as Emerging Anticancer Agents: Current Trends and Recent Advances in Phytotherapy, in Current Aspects of Flavonoids: Their Role in Cancer Treatment, 2019. Crossref

  16. Park Sunwoo, Lim Whasun, You Seungkwon, Song Gwonhwa, Ameliorative effects of luteolin against endometriosis progression in vitro and in vivo, The Journal of Nutritional Biochemistry, 67, 2019. Crossref

  17. Uivarosi Valentina, Munteanu Alexandra Cristina, Sharma Ajay, Singh Tuli Hardeep, Metal Complexation and Patent Studies of Flavonoid, in Current Aspects of Flavonoids: Their Role in Cancer Treatment, 2019. Crossref

  18. Chen Ping, Zhang Jing-Yang, Sha Bei-Bei, Ma Yan-Er, Hu Tao, Ma Yang-Cheng, Sun Hao, Shi Jian-Xiang, Dong Zi-Ming, Li Pei, Luteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450, Oncotarget, 8, 16, 2017. Crossref

  19. Schomberg John, Wang Zi, Farhat Ahmed, Guo Katherine L., Xie Jun, Zhou Zhidong, Liu Jing, Kovacs Bruce, Liu-Smith Feng, Luteolin inhibits melanoma growth in vitro and in vivo via regulating ECM and oncogenic pathways but not ROS, Biochemical Pharmacology, 177, 2020. Crossref

  20. Pirvu Lucia, Neagu Georgeta, Terchescu Iulian, Albu Bujor, Stefaniu Amalia, Comparative studies of two vegetal extracts from Stokesia laevis and Geranium pratense: polyphenol profile, cytotoxic effect and antiproliferative activity, Open Chemistry, 18, 1, 2020. Crossref

  21. Anaya‐Eugenio Gerardo D., Blanco Carcache Peter J., Ninh Tran Ngoc, Ren Yulin, Soejarto Djaja D., Kinghorn A. Douglas, A pentamethoxylated flavone from Glycosmis ovoidea promotes apoptosis through the intrinsic pathway and inhibits migration of MCF ‐7 breast cancer cells , Phytotherapy Research, 35, 3, 2021. Crossref

  22. Huang Liming , Jin Ketao , Lan Huanrong , Luteolin inhibits cell cycle progression and induces apoptosis of breast cancer cells through downregulation of human telomerase reverse transcriptase, Oncology Letters, 2019. Crossref

  23. Nazim Uddin , Park Sang‑Youel , Luteolin sensitizes human liver cancer cells to TRAIL‑induced apoptosis via autophagy and JNK‑mediated death receptor 5 upregulation, International Journal of Oncology, 2018. Crossref

  24. Dong Weimin , Lin Yan , Cao Yang , Liu Yue , Xie Xiaobao , Gu Weiying , Luteolin induces myelodysplastic syndrome‑derived cell apoptosis via the p53‑dependent mitochondrial signaling pathway mediated by reactive oxygen species, International Journal of Molecular Medicine, 2018. Crossref

  25. Ganai Shabir Ahmad, Sheikh Farooq Ahmad, Baba Zahoor Ahmad, Mir Mudasir Ahmad, Mantoo Mohd Ayoob, Yatoo Manzoor Ahmad, Anticancer activity of the plant flavonoid luteolin against preclinical models of various cancers and insights on different signalling mechanisms modulated, Phytotherapy Research, 35, 7, 2021. Crossref

  26. Alsherbiny Muhammad A., Bhuyan Deep J., Radwan Ibrahim, Chang Dennis, Li Chun-Guang, Metabolomic Identification of Anticancer Metabolites of Australian Propolis and Proteomic Elucidation of Its Synergistic Mechanisms with Doxorubicin in the MCF7 Cells, International Journal of Molecular Sciences, 22, 15, 2021. Crossref

  27. Woo Jeong-Hwa, Jang Dae Sik, Choi Jung-Hye, Luteolin Promotes Apoptosis of Endometriotic Cells and Inhibits the Alternative Activation of Endometriosis-Associated Macrophages, Biomolecules & Therapeutics, 29, 6, 2021. Crossref

  28. Starek-Świechowicz Beata, Budziszewska Bogusława, Starek Andrzej, Endogenous estrogens—breast cancer and chemoprevention, Pharmacological Reports, 73, 6, 2021. Crossref

  29. Lee Ho-Sung, Lee In-Hee, Kang Kyungrae, Park Sang-In, Moon Seung-Joon, Lee Chol Hee, Lee Dae-Yeon, Saifudin Azis, A Network Pharmacology Study on the Molecular Mechanisms of FDY003 for Breast Cancer Treatment, Evidence-Based Complementary and Alternative Medicine, 2021, 2021. Crossref

  30. Ho Hsin‐Yu, Chen Ping‐Ju, Lo Yu‐Sheng, Lin Chia‐Chieh, Chuang Yi‐Ching, Hsieh Ming‐Ju, Chen Mu‐Kuan, Luteolin‐7‐O ‐glucoside inhibits cell proliferation and modulates apoptosis through the AKT signaling pathway in human nasopharyngeal carcinoma , Environmental Toxicology, 36, 10, 2021. Crossref

  31. Cotoraci Coralia, Ciceu Alina, Sasu Alciona, Miutescu Eftimie, Hermenean Anca, Bioactive Compounds from Herbal Medicine Targeting Multiple Myeloma, Applied Sciences, 11, 10, 2021. Crossref

  32. Kollur Shiva Prasad, Prasad Shashanka K., Pradeep Sushma, Veerapur Ravindra, Patil Sharanagouda S., Amachawadi Raghavendra G., S Rajendra Prasad, Lamraoui Ghada, Al-Kheraif Abdulaziz A., Elgorban Abdallah M., Syed Asad, Shivamallu Chandan, Luteolin-Fabricated ZnO Nanostructures Showed PLK-1 Mediated Anti-Breast Cancer Activity, Biomolecules, 11, 3, 2021. Crossref

  33. Lipovka Yulia, Alday Efrain, Hernandez Javier, Velazquez Carlos, Molecular Mechanisms of Biologically Active Compounds from Propolis in Breast Cancer: State of the Art and Future Directions, Food Reviews International, 2021. Crossref

  34. Şöhretoğlu Didem, Arroo Randolph, Sari Suat, Huang Shile, Flavonoids as Inducers of Apoptosis and Autophagy in Breast Cancer, in Discovery and Development of Anti-Breast Cancer Agents from Natural Products, 2021. Crossref

  35. Novais Cláudia, Pereira Carla, Molina Adriana K., Liberal Ângela, Dias Maria Inês, Añibarro-Ortega Mikel, Alves Maria José, Calhelha Ricardo C., Ferreira Isabel C.F.R., Barros Lillian, Bioactive and Nutritional Potential of Medicinal and Aromatic Plant (MAP) Seasoning Mixtures, Molecules, 26, 6, 2021. Crossref

  36. Lee Ho-Sung, Lee In-Hee, Kang Kyungrae, Park Sang-In, Jung Minho, Yang Seung Gu, Kwon Tae-Wook, Lee Dae-Yeon, Network Pharmacology-Based Dissection of the Comprehensive Molecular Mechanisms of the Herbal Prescription FDY003 Against Estrogen Receptor-Positive Breast Cancer, Natural Product Communications, 16, 9, 2021. Crossref

  37. Moral Raquel, Escrich Eduard, Influence of Olive Oil and Its Components on Breast Cancer: Molecular Mechanisms, Molecules, 27, 2, 2022. Crossref

  38. Debnath Shibjyoti, Sarkar Abhisek, Mukherjee Dipanwita Das, Ray Subha, Mahata Barun, Mahata Tarun, Parida Pravat K., Das Troyee, Mukhopadhyay Rupak, Ghosh Zhumur, Biswas Kaushik, Eriodictyol mediated selective targeting of the TNFR1/FADD/TRADD axis in cancer cells induce apoptosis and inhibit tumor progression and metastasis, Translational Oncology, 21, 2022. Crossref

  39. Pramodh Sreepoorna, Raina Ritu, Hussain Arif, Bagabir Sali Abubaker, Haque Shafiul, Raza Syed Tasleem, Ajmal Mohammad Rehan, Behl Shalini, Bhagavatula Deepika, Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells, International Journal of Molecular Sciences, 23, 7, 2022. Crossref

  40. Raina Ritu, Pramodh Sreepoorna, Rais Naushad, Haque Shafiul, Shafarin Jasmin, Bajbouj Khuloud, Hamad Mawieh, Hussain Arif, Luteolin inhibits proliferation, triggers apoptosis and modulates Akt/mTOR and MAP kinase pathways in HeLa cells, Oncology Letters, 21, 3, 2021. Crossref

  41. Imran Muhammad, Rauf Abdur, Abu-Izneid Tareq, Nadeem Muhammad, Shariati Mohammad Ali, Khan Imtiaz Ali, Imran Ali, Orhan Ilkay Erdogan, Rizwan Muhammad, Atif Muhammad, Gondal Tanweer Aslam, Mubarak Mohammad S., Luteolin, a flavonoid, as an anticancer agent: A review, Biomedicine & Pharmacotherapy, 112, 2019. Crossref

  42. Soliman Nema A., Abd-Ellatif Rania N., ELSaadany Amira A., Shalaby Shahinaz M., Bedeer Asmaa E., Luteolin and 5-flurouracil act synergistically to induce cellular weapons in experimentally induced Solid Ehrlich Carcinoma: Realistic role of P53; a guardian fights in a cellular battle, Chemico-Biological Interactions, 310, 2019. Crossref

  43. Mohi-ud-din Roohi, Mir Reyaz Hassan, Wani Taha Umair, Alsharif Khalaf F., Alam Waqas, Albrakati Ashraf, Saso Luciano, Khan Haroon, The Regulation of Endoplasmic Reticulum Stress in Cancer: Special Focuses on Luteolin Patents, Molecules, 27, 8, 2022. Crossref

  44. Genovese Carlo, Garozzo Adriana, D’Angeli Floriana, Malfa Giuseppe Antonio, Bellia Francesco, Tomasello Barbara, Nicolosi Daria, Malaguarnera Roberta, Ronsisvalle Simone, Guadagni Fiorella, Acquaviva Rosaria, Orobanche crenata Forssk. Extract Affects Human Breast Cancer Cell MCF-7 Survival and Viral Replication, Cells, 11, 10, 2022. Crossref

  45. Hou Mengyang, Hu Wenzhong, Xiu Zhilong, Shi Yusheng, Hao Kexin, Cao Duo, Guan Yuge, Yin Hanlin, Efficient enrichment of total flavonoids from Pteris ensiformis Burm. extracts by macroporous adsorption resins and in vitro evaluation of antioxidant and antiproliferative activities, Journal of Chromatography B, 1138, 2020. Crossref

  46. Gao Guanglei, Ge Rongli, Li Yuzhou, Liu Shengcui, Luteolin exhibits anti-breast cancer property through up-regulating miR-203, Artificial Cells, Nanomedicine, and Biotechnology, 47, 1, 2019. Crossref

  47. Vachetta Vanina S., Marder Mariel, Troncoso María F., Elola María T., Opportunities, obstacles and current challenges of flavonoids for luminal and triple-negative breast cancer therapy, European Journal of Medicinal Chemistry Reports, 6, 2022. Crossref

  48. Shen Jie, Gu Yongting, Ke Lingjie, Zhang Qiuping, Cao Yin, Lin Yuchao, Wu Zhen, Wu Caisheng, Mu Yuguang, Wu Yun-Long, Ren Changliang, Zeng Huaqiang, Cholesterol-stabilized membrane-active nanopores with anticancer activities, Nature Communications, 13, 1, 2022. Crossref

  49. Prasher Parteek, Sharma Mousmee, Singh Sachin Kumar, Gulati Monica, Chellappan Dinesh Kumar, Zacconi Flavia, De Rubis Gabriele, Gupta Gaurav, Sharifi-Rad Javad, Cho William C., Dua Kamal, Luteolin: a flavonoid with a multifaceted anticancer potential, Cancer Cell International, 22, 1, 2022. Crossref

  50. Singh Tuli Hardeep, Rath Prangya, Chauhan Abhishek, Sak Katrin, Aggarwal Diwakar, Choudhary Renuka, Sharma Ujjawal, Vashishth Kanupriya, Sharma Sheetu, Kumar Manoj, Yadav Vikas, Singh Tejveer, Yerer Mukerrem Betul, Haque Shafiul, Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives, Cancers, 14, 21, 2022. Crossref

2478 Visualizações do artigo 74 downloads de artigos Métricas
2478 VISUALIZAÇÕES 74 TRANSFERÊNCIAS 50 Crossref CITAÇÕES Google
Scholar
CITAÇÕES

Artigos com conteúdo semelhante:

Sinigrin Impedes the Breast Cancer Cell Growth through the Inhibition of PI3K/AKT/mTOR Phosphorylation-Mediated Cell Cycle Arrest Journal of Environmental Pathology, Toxicology and Oncology, Vol.41, 2022, issue 3
Jiawen Lin, Shuqin Li, Lingzhi Zhou, Peishun Wang, Shaohua Qu, Jiaofei Wei
Luteolin Induces Growth Arrest in Colon Cancer Cells Through Involvement of Wnt/β-Catenin/GSK-3β Signaling Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 2
Ashok Kumar Pandurangan, Prakash Dharmalingam, Manikandan Ramar, Arumugam Munusamy, Suresh Kumar Ananda Sadagopan, Ashok Kumar Pandurangan
Bacillus thuringiensis Parasporal Proteins Induce Cell-Cycle Arrest and Caspase-Dependant Apoptotic Cell Death in Leukemic Cells Journal of Environmental Pathology, Toxicology and Oncology, Vol.31, 2012, issue 1
Vishna Devi Nadarajah, Rebecca Shin-Yee Wong, Tengku Azmi Tengku Ibrahim, KoK-Keong Chan, Shar Mariam Mohamed, Maha Abdullah
Effect of Ukrain on Cell Survival and Apoptosis in the Androgen-Independent Prostate Cancer Cell Line PC-3 Journal of Environmental Pathology, Toxicology and Oncology, Vol.30, 2011, issue 1
Sivakamasundari Velayutham, Sharmila Govindaraj, Arunakaran Jagadeesan, Kavitha Venkatesh, Arunkumar Ramachandran, Elumalai Perumal, Senthilkumar Kalimuthu
Comparative Study on the Effect of Aqueous and Ethanolic Mycelial Extracts from Polycephalomyces nipponicus (Ascomycetes) against Human Breast Cancer MCF-7 Cells International Journal of Medicinal Mushrooms, Vol.21, 2019, issue 7
Benjaporn Buranrat, Aphidech Sangdee, Kusavadee Sangdee
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain