Inscrição na biblioteca: Guest
Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

Effect of Ginkgo biloba Extract on Lead-Induced Oxidative Stress in Different Regions of Rat Brain

Volume 34, Edição 2, 2015, pp. 161-173
DOI: 10.1615/JEnvironPatholToxicolOncol.2015013095
Get accessGet access

RESUMO

Ginkgo biloba extract (GbE) is a well known natural antioxidant. In the present investigation, its ameliorative effects were tested against lead-induced oxidative stress in rat brain. Four groups of male Wistar rats (100 to 120 g) were used, consisting of eight rats per group. Rats in the control group received 500 ppm of sodium acetate through drinking water, and rats in the other three groups received 500 ppm of lead acetate through drinking water for 4 weeks. Rats in the third and fourth groups were administered (oral) 50 and 100 mg/kg of GbE, respectively, along with lead acetate. The rats were sacrificed after treatment and brains were isolated. Each brain was dissected on ice, and different regions, namely the cerebellum, hippocampus, frontal cortex, and brainstem, were separated. The results revealed a significant (P < .001) increase in reactive oxygen species, catalase, superoxide dismutase, lipid peroxidation products, and total protein carbonyl content, relative to their controls, in all four regions of the brain exposed to lead. These results indicate oxidative stress. Partial restoration was observed for all the parameters just mentioned in different brain regions on treatment with 50 mg/kg GbE. This amelioration was higher with 100 mg/kg GbE, showing dose-dependency. Overall the data suggest that GbE protects against lead-induced oxidative stress in specific regions of rat brain.

CITADO POR
  1. Wang Congpin, Wang Bin, Ginkgo Biloba Extract Attenuates Oxidative Stress and Apoptosis in Mouse Cochlear Neural Stem Cells, Phytotherapy Research, 30, 5, 2016. Crossref

  2. Inozemtsev A. N., Bokieva S. B., Karpukhina O. V., Gumargalieva K. Z., Kamensky A. A., Myasoedov N. F., Semax prevents learning and memory inhibition by heavy metals, Doklady Biological Sciences, 468, 1, 2016. Crossref

  3. El Tabaa Manar Mohammed, Sokkar Samia Salem, Ramadan Ehab Sayed, Abd El Salam Inas Zakria, Zaid Anis, Neuroprotective role of Ginkgo biloba against cognitive deficits associated with Bisphenol A exposure: An animal model study, Neurochemistry International, 108, 2017. Crossref

  4. Dai Chun-Xiao, Hu Chang-Chun, Shang Yu-Shan, Xie Jian, Role of Ginkgo biloba extract as an adjunctive treatment of elderly patients with depression and on the expression of serum S100B, Medicine, 97, 39, 2018. Crossref

  5. Kuang Shaosong, Yang Lin, Rao Ziliang, Zhong Zhiyong, Li Jinfeng, Zhong Haichao, Dai Lulu, Tang Xiaojiang, Effects of Ginkgo Biloba Extract on A53T α-Synuclein Transgenic Mouse Models of Parkinson’s Disease, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 45, 2, 2018. Crossref

  6. Koriem Khaled M. M., Arbid Mahmoud S., Role of caftaric acid in lead-associated nephrotoxicity in rats via antidiuretic, antioxidant and anti-apoptotic activities, Journal of Complementary and Integrative Medicine, 15, 2, 2018. Crossref

  7. Hirata Bruna K.S., Pedroso Amanda P., Machado Meira M.F., Neto Nelson I.P., Perestrelo Bruna O., de Sá Roberta D.C.C., Alonso-Vale Maria Isabel C., Nogueira Fernando N., Oyama Lila M., Ribeiro Eliane B., Tashima Alexandre K., Telles Monica M., Ginkgo biloba Extract Modulates the Retroperitoneal Fat Depot Proteome and Reduces Oxidative Stress in Diet-Induced Obese Rats, Frontiers in Pharmacology, 10, 2019. Crossref

  8. Omidkhoda Seyedeh Farzaneh, Razavi BiBi Marjan, Hosseinzadeh Hossein, Protective effects of Ginkgo biloba L. against natural toxins, chemical toxicities, and radiation: A comprehensive review , Phytotherapy Research, 33, 11, 2019. Crossref

  9. Calabrese Edward J., Calabrese Vittorio, Tsatsakis Aristidis, Giordano James J., Hormesis and Ginkgo biloba (GB): Numerous biological effects of GB are mediated via hormesis, Ageing Research Reviews, 64, 2020. Crossref

  10. Adebayo Olusegun G., Ben-Azu Benneth, Ajayi Abayomi M., Wopara Iheanyichukwu, Aduema Wadioni, Kolawole Tolunigba A., Umoren Elizabeth B., Onyeleonu Ijeoma, Ebo Oloruntoba T., Ajibo Doris N., Akpotu Ajirioghene E., Gingko biloba abrogate lead-induced neurodegeneration in mice hippocampus: involvement of NF-κB expression, myeloperoxidase activity and pro-inflammatory mediators, Biological Trace Element Research, 200, 4, 2022. Crossref

  11. Wang Ke, Chen Yuan, Zhu Xue, Zou Wenjun, Zhou Fanfan, Ginkgo biloba Extract Attenuates Light-Induced Photoreceptor Degeneration by Modulating CAV-1—Redoxosome Signaling, Antioxidants, 11, 7, 2022. Crossref

  12. Ben-Azu Benneth, Adebayo Olusegun G., Wopara Iheanyichukwu, Aduema Wadioni, Onyeleonu Ijeoma, Umoren Elizabeth B., Kolawole Tolunigba A., Ebo Oloruntoba T., Akpotu Ajirioghene E., Ajibo Doris N., Onuoha Ogechukwu G., Lead acetate induces hippocampal pyramidal neuron degeneration in mice via up-regulation of executioner caspase-3, oxido-inflammatory stress expression and decreased BDNF and cholinergic activity: Reversal effects of Gingko biloba supplement, Journal of Trace Elements in Medicine and Biology, 71, 2022. Crossref

  13. Osman Amr S., Abu-Risha Sally E., Bakr Samaa M., Altyar Ahmed E., Fayad Eman, EL-Sawi Mamdouh R., EL-Kholy Wafaa M., Comparative study between effects of ginkgo biloba extract and extract loaded on gold nanoparticles on hepatotoxicity induced by potassium bromate, Environmental Science and Pollution Research, 2022. Crossref

  14. Sirasanagandla Srinivasa Rao, Al-Huseini Isehaq, Sakr Hussein, Moqadass Marzie, Das Srijit, Juliana Norsham, Abu Izuddin Fahmy, Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use, Molecules, 27, 17, 2022. Crossref

  15. Boateng Isaac Duah, Potentialities of Ginkgo extract on toxicants, toxins, and radiation: a critical review, Food & Function, 13, 15, 2022. Crossref

  16. Barth Stephan W., Lehner Martin D., Dietz Gunnar P.H., Schulze Holger, Pharmacologic treatments in preclinical tinnitus models with special focus on Ginkgo biloba leaf extract EGb 761®, Molecular and Cellular Neuroscience, 116, 2021. Crossref

Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa Políticas de preços e assinaturas Begell House Contato Language English 中文 Русский Português German French Spain