Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Protective Effect of Infliximab Against Carbon Tetrachloride−Induced Hepatotoxicity
RESUMO
Carbon tetrachloride (CCl4), a solvent frequently used in industry, can cause acute liver failure and liver fibrosis. Infliximab (Ib), a potent tumor necrosis factor alpha blocker, has a protective effect on the liver. Therefore, we investigated the protective effect of Ib against CCl4-induced acute liver injury. In this study, 24 male Sprague Dawley rats were randomly divided into three groups: the control group (n = 8), the CCl4 group (n = 8), and the CCl4 + Ib group (n = 8). A single dose of 2 mL/kg CCL4 was administered to the CCL4 group. The CCl4 + Ib group was injected with a single dose (7 mg/kg) of Ib 24 h before CCl4 was administered. In the CCl4 group, the serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and the liver tissue levels of transforming growth factor beta 1 (TGF-β1), interleukin 1 beta (IL-1β), and adenosine deaminase (ADA) were significantly higher than the levels of these same substances in the control and CCl4 + Ib groups. The histopathological investigation revealed that although there was excessive liver injury in the CCl4 group, there was reduced injury in the CCl4 + Ib group. In addition, the carbamoyl phosphate synthetase I (CPS-I) and carbonic anhydrase II (CA-II) levels in the CCl4 group were significantly lower than those in the control and CCl4 + Ib groups. The results show that during CCl4-induced hepatotoxicity, Ib prevents liver injury by suppressing TGF-β1 and IL-1β levels, decreasing ADA levels, and regulating CPS-I and CA-II enzyme levels.
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Dufton Neil P., Peghaire Claire R., Osuna-Almagro Lourdes, Raimondi Claudio, Kalna Viktoria, Chauhan Abhishek, Webb Gwilym, Yang Youwen, Birdsey Graeme M., Lalor Patricia, Mason Justin C., Adams David H., Randi Anna M., Dynamic regulation of canonical TGFβ signalling by endothelial transcription factor ERG protects from liver fibrogenesis, Nature Communications, 8, 1, 2017. Crossref
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Ozdemir Ali, Tumkaya Levent, Kalcan Suleyman, Uyan Mikail, Karakaya Ahmet, Demiral Gokhan, Celik Samanci Tugba, Mercantepe Tolga, Cumhur Cüre Medine, Cüre Erkan, The effects of TNF-α inhibitors on carbon tetrachloride-induced nephrotoxicity, Clinical and Experimental Hypertension, 44, 3, 2022. Crossref
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Chen Ting, Huang Zhigang, Chen Wei, Ding Ru, Li Na, Cui Haiming, Wu Feng, Liang Chun, Cong Xiaoliang, Potential cardioprotective influence of bupropion against CCl4-triggered cirrhotic cardiomyopathy, Arabian Journal of Chemistry, 15, 3, 2022. Crossref