Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Journal of Environmental Pathology, Toxicology and Oncology
Fator do impacto: 1.241 FI de cinco anos: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2016015892
pages 161-169

Naringenin Alleviates Cadmium-Induced Toxicity through the Abrogation of Oxidative Stress in Swiss Albino Mice

Avratanu Das
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India
Amrita Roy
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India
Ruma Das
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal India
Sanjib Bhattacharya
Faculty of Pharmaceutical Sciences, PCTE Group of Institutes, Ludhiana 142021, Punjab, India
Pallab Kanti Haldar
Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, West Bengal, India

RESUMO

The present study evaluates the protective potential of the flavonoid naringenin (NRG) against experimentally induced cadmium (Cd) toxicity in Swiss albino mice. NRG (4 and 8 mg/kg) was orally administered to mice 30 min before oral administration of CdCl2 (12 mg/kg) for 11 consecutive days. On the 12th day, we evaluated body and organ weights, hematological profiles, serum biochemical profiles, and hepatic and renal tissue antioxidative parameters including lipid peroxidation, reduced and oxidized glutathione, glutathione-S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase, and catalase. Cotreatment with NRG markedly and significantly normalized body and organ weights, hematological profiles, and serum biochemical profiles and significantly modulated all of the hepatic and renal tissue biochemical parameters in Cd-intoxicated mice. The present findings show that NRG possesses a remarkable alleviative effect against Cd-induced toxicity in albino mice, mediated by abrogation of Cd-induced oxidative stress by multiple mechanisms.


Articles with similar content:

Naringenin, a Citrus Flavonoid, Ameliorates Arsenic-Induced Toxicity in Swiss Albino Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.33, 2014, issue 3
Ruma Das, Avratanu Das, Sanjib Bhattacharya, Amrita Roy, Sagnik Haldar, Pallab Kanti Haldar
Trichosanthes dioica Fruit Extract Ameliorates Arsenic-Induced Brain Toxicity in Male Albino Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 2
Sanjib Bhattacharya, Pallab Kanti Haldar
Trichosanthes dioica Root Alleviates Arsenic Induced Myocardial Toxicity in Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.32, 2013, issue 3
Sanjib Bhattacharya, Pallab Kanti Haldar
The Hepatoprotective Effect of Clidemia hirta against Carbon Tetrachloride (CCl4)−Induced Oxidative Stress and Hepatic Damage in Mice
Journal of Environmental Pathology, Toxicology and Oncology, Vol.36, 2017, issue 4
Mohammad Iqbal, Nurul Amzar
Hepatoprotective and Immunosuppressive Effect of Synedrella nodiflora L. on Carbon Tetrachloride (CCl4)-Intoxicated Rats
Journal of Environmental Pathology, Toxicology and Oncology, Vol.35, 2016, issue 1
Muhammad Dawood Shah, A.T.M. Emdadul Haque, Mohammad Iqbal, Jaafar Sadeq Makki, Charles Gnanaraj