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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Effects of Maternally Exposed Food Coloring Additives on Laryngeal Histology in Rats

Volume 33, Edição 2, 2014, pp. 123-130
DOI: 10.1615/JEnvironPatholToxicolOncol.2014008723
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RESUMO

Experimental reports showed carcinogenic effects of artificial food colors and additives (AFCAs) on many organs, including the head and neck region. We aimed to investigate the effect of AFCAs on laryngeal histomorphology and immunohistochemical expression in maternally exposed rats. "No observable adverse effect levels" of commonly used AFCAs as a mixture were given to female rats before and during gestation. Histopathological and immunohistochemical findings were evaluated in their offspring. Significant decreasing in goblet cell count and cilia loss were observed with AFCAs in maternally exposed rats (p < 0.05). Immunohistochemically, the Ki67 index was significantly increased and villin expression was significantly reduced in laryngeal epithelium in the study group (p < 0.05), whereas expression of cyclooxygenase type 2, Muc-2, Muc-5AC, p53, and epidermal growth factor receptors did not differ between the groups. This study demonstrated that maternal exposure of AFCAs plays a role in the mucosal defense system and possibly in carcinogenesis.

CITADO POR
  1. Arroz Erin, Jordan Michael, Dumancas Gerard G., Development of a Direct Spectrophotometric and Chemometric Method for Determining Food Dye Concentrations, Applied Spectroscopy, 71, 7, 2017. Crossref

  2. Başak Kayhan, Demir Mehmet Gökhan, Altıntoprak Niyazi, Aydın Sedat, The Effect of Antioxidant Agents on Cisplatin-Induced Laryngeal Histological Alterations in Rats, Journal of Medicinal Food, 24, 2, 2021. Crossref

  3. Savas Hasan Basri, Gultekin Fatih, Basak Kayhan, Aylak Firdevs, Doguc Duygu Kumbul, Gurdal Osman, Salivary glands of fetuses are adversely affected by artificial food colorings in rats, Revista da Associação Médica Brasileira, 67, 2, 2021. Crossref

  4. Gentry Robinan, Greene Tracy, Chappell Grace, Lea Isabel, Borghoff Susan, Yang Chihae, Rathman James, Ribeiro João Vinnie, Hobocienski Bryan, Mostrag Aleksandra, Rodricks Joseph, Clewell Harvey, Integration of evidence to evaluate the potential for neurobehavioral effects following exposure to USFDA-approved food colors, Food and Chemical Toxicology, 151, 2021. Crossref

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