Inscrição na biblioteca: Guest
Portal Digital Begell Biblioteca digital da Begell eBooks Diários Referências e Anais Coleções de pesquisa
Journal of Environmental Pathology, Toxicology and Oncology
Fator do impacto: 1.241 FI de cinco anos: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvPathToxOncol.v24.i2.70
pages 141-144

Black Tea (Camellia sinensis) as a Chemopreventive Agent in Oral Precancerous Lesions

Ajanta Halder
Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata, India
Ranjan Raychowdhury
Department of ENT Surgery, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata, India
Asish Ghosh
Department of Facial and Maxillary Surgery, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata, India
Madhusnata De
Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata, India

RESUMO

Oral carcinoma is the most common malignancy found in adult Indian men and the third most common in adult Indian women. About half of all cases are found to be associated with precancerous lesions, chiefly leukoplakia. We wanted to explore the possible benefits of black tea (Camellia sinensis) administered to patients with oral leukoplakia. Eighty-two subjects with oral leukoplakia underwent micronuclei and chromosomal assays on exfoliated oral mucosal epithelium, after which they received black tea in a fixed regimen. The micronuclei assay was repeated at 6 months, and the chromosomal study at 1 year. After the first year, the first 15 patients entered onto this study showed a significant decrease in the micronuclei frequency and chromosomal aberrations, which correlated with the clinical improvement. Several in vitro and animal studies have suggested the efficacy of tea in the chemoprevention of cancer. To the best of our knowledge, this is the first report on the effect of black tea in oral leukoplakia.


Articles with similar content:

Use of Black Tea in Modulating Clastogenic Effects of Arsenic in Mice In Vivo
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 3
Ajanta Halder, Madhusnata De, Niladri Bhowmik, Manomita Patra
Arsenic-Induced Micronuclei Formation in Mammalian Cells and Its Counteraction by Tea
Journal of Environmental Pathology, Toxicology and Oncology, Vol.24, 2005, issue 1
Maqsood Siddiqi, Madhumita Roy, Rathindra Kumar Bhattacharya, Dona Sinha
Chromosomal Aberrations in Subjects Exposed to Ionizing Radiation
Journal of Environmental Pathology, Toxicology and Oncology, Vol.28, 2009, issue 1
Tanja D. Vukov, Snezana Milacic, Dubravka Jovicic, Nenad Bukvic, Natasa Milic
Photobiomodulation in the Treatment of Muscle Injury: A Systematic Review
Critical Reviews™ in Physical and Rehabilitation Medicine, Vol.30, 2018, issue 1
Felipe Rodolfo Pereira da Silva, Marcelo de Carvalho Filgueiras, Yago Medeiros Dutra, Ramon Handerson Gomes Teles, Thiago Pereira dos Santos, José Carlos Raposo Mazulo Neto, Tarcisio Vieira de Brito, Isabela de Souza Brauna, Donária Bezerra Nobre do Vale, Saul Barbosa de Oliveira, Mariana de Souza Costa
In Vitro Mitigation of Arsenic Toxicity by Tea Polyphenols in Human Lymphocytes
Journal of Environmental Pathology, Toxicology and Oncology, Vol.26, 2007, issue 3
Subhabrata Dey, Madhumita Roy, Rathindra Kumar Bhattacharya, Dona Sinha