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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Effect of Benzo[a]pyrene on the Production of Vascular Endothelial Growth Factor by Human Eosinophilic Leukemia EoL-1 Cells

Volume 30, Edição 3, 2011, pp. 241-249
DOI: 10.1615/JEnvironPatholToxicolOncol.v30.i3.70
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RESUMO

Benzo[a]pyrene (BaP) has been shown to affect both the development and response of T and B cells in the immune system. However, the effect of BaP on other immune cells, such as eosionophils, is unknown. In this study, we investigated the effect of BaP on the production of vascular endothelial growth factor (VEGF) using an in vitro eosinophilic EoL-1 cell and human umbilical vein endothelial cell (HUVEC) co-culture system. EoL-1−conditioned medium was found to promote the growth of HUVEC in a time-dependent manner. The growth stimulating activity was due to the production of VEGF by the EoL-1 cells. The production of VEGF was correlated with the enhanced expression of the phosphorylated form of extracellular signal-regulated kinases (p-ERKs) and the upregulated expression of VEGF mRNA. Furthermore, BaP-induced expression of VEGF mRNA was reduced by the ERK inhibitor PD98059. Results from this study suggested that BaP might affect the growth of endothelial cells through the modulation of VEGF production by eosinophils.

Palavras-chave: BaP, EoL-1, HUVEC, VEGF, co-culture
CITADO POR
  1. Maciel Érica Santos, Biasibetti Regina, Costa Ana Paula, Lunardi Paula, Schunck Rebeca Vargas Antunes, Becker Gabriela Curbeti, Arbo Marcelo Dutra, Dallegrave Eliane, Gonçalves Carlos Alberto, Saldiva Paulo H. Nascimento, Garcia Solange Cristina, Leal Rodrigo Bainy, Leal Mirna Bainy, Subchronic Oral Administration of Benzo[a]pyrene Impairs Motor and Cognitive Behavior and Modulates S100B Levels and MAPKs in Rats, Neurochemical Research, 39, 4, 2014. Crossref

  2. Mavrofrydi Olga, Mavroeidi Panagiota, Papazafiri Panagiota, Comparative assessment of HIF-1α and Akt responses in human lung and skin cells exposed to benzo[α]pyrene: Effect of conditioned medium from pre-exposed primary fibroblasts, Environmental Toxicology, 31, 9, 2016. Crossref

  3. Xu Dan, Li Shuai, Lin Limei, Qi Fei, Hang Xiaoming, Sun Yeqing, Gene expression profiling to identify the toxicities and potentially relevant disease outcomes due to endosulfan exposure, Toxicology Research, 5, 2, 2016. Crossref

  4. Lin Cheng-Kuan, Hsu Yu-Tien, Christiani David C., Hung Huei-Yang, Lin Ro-Ting, Risks and burden of lung cancer incidence for residential petrochemical industrial complexes: A meta-analysis and application, Environment International, 121, 2018. Crossref

  5. Fu Chenghao, Li Yuemin, Xi Hao, Niu Zemiao, Chen Ning, Wang Rong, Yan Yonghuan, Gan Xiaoruo, Wang Mengtian, Zhang Wei, Zhang Yan, Lv Pin, Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism, Frontiers in Nutrition, 9, 2022. Crossref

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