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Journal of Environmental Pathology, Toxicology and Oncology
Fator do impacto: 1.625 FI de cinco anos: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2013009650
pages 263-273

Dosimetry and Radiobiological Studies of Automated Alpha-Particle Irradiator

Jyothish Babu M V
Mechanical Design and Prototype Development Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
Sanjay G. Shinde
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
Sunil Kumar S
Mechanical Design and Prototype Development Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India; LPSC-ISRO, Thiruvananthapuram Kerala, India
Manjoor Ali
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai - 400085, India
R. Vasumathy
Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India
Amit Kumar
Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
R. V. Kolekar
Radiation Safety System Division; Bhabha Atomic Research Center, Trombay, Mumbai, India
Manish Kumar
Mechanical Design and Prototype Development Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
P. K. Nema
Mechanical Design and Prototype Development Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
P.V. Bhagwat
Mechanical Design and Prototype Development Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
Badri Narain Pandey
Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Mumbai, India

RESUMO

Understanding the effect of alpha radiation on biological systems is an important component of radiation risk assessment and associated health consequences. However, due to the short path length of alpha radiation in the atmosphere, in vitro radiobiological experiments cannot be performed with accuracy in terms of dose and specified exposure time. The present paper describes the design and dosimetry of an automated alpha-particle irradiator named 'BARC BioAlpha', which is suitable for in vitro radiobiological studies. Compared to alpha irradiators developed in other laboratories, BARC BioAlpha has integrated computer-controlled movement of the alpha-particle source, collimator, and electronic shutter. The diaphragm blades of the electronic shutter can control the area (diameter) of irradiation without any additional shielding, which is suitable for radiobiological bystander studies. To avoid irradiation with incorrect parameters, a software interlock is provided to prevent shutter opening, unless the user-specified speed of the source and collimator are achieved. The dosimetry of the alpha irradiator using CR-39 and silicon surface barrier detectors showed that ~4 MeV energy of the alpha particle reached the cells on the irradiation dish. The alpha irradiation was also demonstrated by the evaluation of DNA double-strand breaks in human cells. In conclusion, 'BARC BioAlpha' provides a user-friendly alpha irradiation system for radiobiological experiments with a novel automation mechanism for better accuracy of dose and exposure time.


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