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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

Indexed in

In Silico Analysis and Validation of the Proliferative Potential of CLDN1 Expression in Gastric Cancer

Volume 32, Edição 4, 2013, pp. 343-360
DOI: 10.1615/JEnvironPatholToxicolOncol.2013008555
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RESUMO

Tight junction protein claudin-1 (CLDN1) is mainly involved in the intercellular barrier function of epithelial cells and is known to be dysregulated in many cancer types, including gastrointestinal cancers. However, the mechanisms behind their potential involvement in the proliferation and survival of tumor cells remain unexplored. In this study we sought to investigate the potential role and possible regulators of CLDN1 in gastric cancer. By analyzing the gastric tumors from publicly available genome-wide messenger RNA expression profiles, CLDN1 was identified to be overexpressed in gastric tumors when compared with normal gastric tissues. Association between CLDN1 expression and clinical molecular subtype characteristics of gastric cancer showed an elevated CLDN1 expression pattern in intestinal and proliferative types of gastric cancer. Using in vitro CLDN1 perturbation analysis in gastric cancer cell lines, we confirmed the potential role of CLDN1 in cellular proliferation. Aided by the integrative analysis of the pathway prediction method with CLDN1 expression in gastric tumors, we demonstrated the negative association between estrogen-α and CLDN1 expression in gastric tumors. Our results highlight the potential involvement of CLDN1 expression in gastric cancer.

CITADO POR
  1. Pandi Narayanan Sathiya, Manimuthu Muthaiah, Harunipriya Palaniswamy, Murugesan Manikandan, Asha George Virumaandi, Rajendran Suriliyandi, In silico analysis of expression pattern of a Wnt/β-catenin responsive gene ANLN in gastric cancer, Gene, 545, 1, 2014. Crossref

  2. Li Guanghua, Wu Libo, Yu Jiaxing, Zhai Siyang, Deng Hailong, Wang Qiushi, Zhang Zhiqian, Identification and Validation of Three-Gene Signature in Lung Squamous Cell Carcinoma by Integrated Transcriptome and Methylation Analysis, Journal of Oncology, 2022, 2022. Crossref

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