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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Decreased T-Cell Proliferation and Skewed Immune Responses in LLC-Bearing Mice

Volume 24, Edição 3, 2005, pp. 175-192
DOI: 10.1615/JEnvPathToxOncol.v24.i3.40
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RESUMO

Deficits in immune cell responses have been reported in cancer patients. We used the murine Lewis lung carcinoma (LLC) model to better understand these deficits. The goal of this study was to determine if the immune responses of LLC tumor-bearing (TB) mice differ from control mice and whether the difference could be attributed to either antigen-presenting cells (FPC) or to T cells. Tumors were first allowed to grow in vivo for approximately 2 weeks. Splenocytes were then isolated for in vitro proliferation and cytokine release studies. The results showed a decrease in mitogen-stimulated proliferation by unfractionated splenocyte cultures from TB mice when compared to control mice in response to concanavalin A (Con A), a T-cell mitogen. Decreased responses were also observed when the APC spleen cell fraction from TB mice was cultured with normal T cells, although proliferation was more prominently reduced in cultures of TB T cells plus normal APC. Also, splenocytes from TB mice secreted significantly increased levels of IFN-γ, IL-4, and IL-10. Admixing APC from control mice with TB T cells significantly decreased levels of IL-4 and IL-10 secretion as compared to the levels secreted by cocultures of TB T cells and TB APC. The decreased cytokine profile in the presence of normal APC despite the presence of TB T cells suggests that APC contributes to the immune dysfunction, including Th skewing of tumor bearers, possibly through their influence on T-cell expansion and cytokine production. Fınally, our assessment of the APC population contributing to the observed immune dysfunction-i.e., dendritic cells or macrophages-showed that the proliferation of TB T cells was decreased regardless of the APC population with which they were cocultured. However, normal T-cell proliferation was only reduced by the addition of TB macrophages and not by the addition of TB dendritic cells. In conclusion, our results demonstrate that LLC TB mice have a skewed immune response characterized by a decreased proliferative response with both T cells and APC affected by the presence of tumor.

CITADO POR
  1. Miller Andrew C., Rashid Rashid M., Elamin Elamin M., The “T” in Trauma: the Helper T-cell Response and the Role of Immunomodulation in Trauma and Burn Patients, Journal of Trauma: Injury, Infection & Critical Care, 63, 6, 2007. Crossref

  2. Rashid Rashid M., Miller Andrew, Scianna Joseph M., Stankiewicz James A., Chronic rhinosinusitis and psoriasis: do mutually exclusive systemic Th1 and Th2 disease patterns exist?, Acta Oto-Laryngologica, 127, 7, 2007. Crossref

  3. Kushida Shigeki, Ohmae Hiroshi, Kamma Hiroshi, Totsuka Rumiko, Matsumura Masayuki, Takeuchi Akira, Saiki Ikuo, Yanagawa Toru, Onizawa Kojiro, Ishii Tetsuro, Ohno Tadao, Artificial cytokine storm combined with hyperthermia induces significant anti-tumor effect in mice inoculated with Lewis lung carcinoma and B16 melanoma cells, International Journal of Hyperthermia, 22, 8, 2006. Crossref

  4. Luo Xian, Slater James M., Gridley Daila S., Radiation and Endostatin Gene Therapy in a Lung Carcinoma Model: Pilot Data on Cells and Cytokines that Affect Angiogenesis and Immune Status, Technology in Cancer Research & Treatment, 5, 2, 2006. Crossref

  5. Premkumar Kavitha, Shankar Bhavani S., TGF-βR inhibitor SB431542 restores immune suppression induced by regulatory B–T cell axis and decreases tumour burden in murine fibrosarcoma, Cancer Immunology, Immunotherapy, 70, 1, 2021. Crossref

  6. Zelenskyi E. A., Rutto K. V., Kudryavtsev I. V., Sokolov A. V., Kisseleva E. P., Iron Content and Cellular Proliferation in Thymus and Spleen of Hepatoma 22A Bearing Mice, Cell and Tissue Biology, 15, 4, 2021. Crossref

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