Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
COX-2 and Prostanoid Receptors: Good Targets for Chemoprevention
RESUMO
Accumulating evidence indicates that COX-2 inhibitors are involved in colon and breast cancer development. Our previous studies indicated that nimesulide and celecoxib, selective COX-2 inhibitors, show inhibitory effects of intestinal" carcinogenesis in azoxymethane-treated rats and mice and in Min mice models. We recently found that nimesulide suppressed PhIP-induced breast cancer in female SD rats in which COX-2 protein was overexpressed. These results led us to investigate the effects of prostaglandin E2(PGE2) in the target tissues. PGE2 showed its biological activity through binding to its membrane receptors, EP1~4. We also investigated the effects of EP receptors on colon carcinogenesis. We used receptor knockout mice and selective receptor antagonists. Our results indicated that the EP1 receptor plays a pivotal role in colon carcinogenesis. Selective EP1 receptor antagonists may be a new class of chemopreventive agents against colon cancer.
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de Souza Filho J P, Correa Z M S, Marshall J C, Anteka E, Coutinho A B, Martins M C, M N Burnier , The effect of a selective cyclooxygenase-2 (COX-2) inhibitor on the proliferation rate of retinoblastoma cell lines, Eye, 20, 5, 2006. Crossref
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Gustafsson Annika, Hansson Elisabeth, Kressner Ulf, Nordgren Svante, Andersson Marianne, Wang Wenhua, Lönnroth Christina, Lundholm Kent, EP1–4 subtype, COX and PPARγ receptor expression in colorectal cancer in prediction of disease-specific mortality, International Journal of Cancer, 121, 2, 2007. Crossref
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Souza Filho João Pessoa, Martins Maria C., Correa Zelia Maria S., Odashiro Alexandre N., Antecka Emilia, Coutinho Anamaria B., Macedo Carla R., Vianna Raul N.G., Burnier Miguel N., The Expression of Cyclooxygenase 2 in Retinoblastoma: Primary Enucleated Eyes and Enucleation After Conservative Treatment, American Journal of Ophthalmology, 142, 4, 2006. Crossref
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Yang David J., Bryant Jerry, Chang Joe Y., Mendez Richard, Oh Chang-Sok, Yu Dong-Fang, Ito Megumi, Azhdarinia Ali, Kohanim Sahar, Edmund Kim E., Lin Edward, Podoloff Donald A., Assessment of cyclooxygense-2 expression with 99mTc-labeled celebrex, Anti-Cancer Drugs, 15, 3, 2004. Crossref
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Wobst Ivonne, Schiffmann Susanne, Birod Kerstin, Maier Thorsten J., Schmidt Ronald, Angioni Carlo, Geisslinger Gerd, Grösch Sabine, Dimethylcelecoxib inhibits prostaglandin E2 production, Biochemical Pharmacology, 76, 1, 2008. Crossref
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Gu Pingqing, Su Yajuan, Guo Shuyu, Teng Lichen, Xu Ye, Qi Juan, Gong Hui, Cai Youqun, Over-Expression of COX-2 Induces Human Ovarian Cancer Cells (CAOV-3) Viability, Migration and Proliferation in Association with PI3-k/Akt Activation, Cancer Investigation, 26, 8, 2008. Crossref
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Miliaras S., Anogeianaki A., Meditskou S., Kefala V., Koutsonikolas D., Liangouris J., Anogianakis G., Miliaras D., Effects of Rich-in-Fat Diets and Highly Selective COX-2 Inhibitors on 7,12-Dimethylbenz-(A)-Anthracene-Induced Tumor Growth, International Journal of Immunopathology and Pharmacology, 22, 2, 2009. Crossref
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Smedh Ulrika, Gustafsson Annika, Axelsson Hans, Cahlin Christian, Lönnroth Christina, Lundholm Kent, The Impact of Inflammation Control and Active Cancer Palliation on Metabolic Pathways Determining Tumor Progression and Patient Survival, in From Molecular to Modular Tumor Therapy, 2010. Crossref
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Rainsford K. D., Pharmacology and toxicology of COX-2 inhibitors, in COX-2 Inhibitors, 2004. Crossref
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Rask Katarina, Zhu Yihong, Wang Wanzhong, Hedin Lars, Sundfeldt Karin, Ovarian epithelial cancer: a role for PGE2-synthesis and signalling in malignant transformation and progression, Molecular Cancer, 5, 1, 2006. Crossref
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Takakusagi Yoichi, Ohta Keisuke, Kuramochi Kouji, Morohashi Kengo, Kobayashi Susumu, Sakaguchi Kengo, Sugawara Fumio, Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology, Bioorganic & Medicinal Chemistry Letters, 15, 21, 2005. Crossref