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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Exogenous Surfactant Suppresses Inflammation in Experimental Endotoxin-Induced Lung Injury

Volume 28, Edição 4, 2009, pp. 341-349
DOI: 10.1615/JEnvironPatholToxicolOncol.v28.i4.80
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RESUMO

Our objective was to evaluate the anti-inflammatory effects of exogenous surfactant and surfactant phospholipids on the lipopolysaccharide (LPS)-induced lung injury. Exogenous surfactant (porcine surfactant) and surfactant phospholipid (dipalmitoyl phospholipid DPPC, hexadecanol, tylaxopol) were instilled intratracheally with LPS in rats. Expression of surfactant apoproteins (SP-A) and the cyclooxygenase enzymes (COX-1 and -2) was studied by immunohistochemistry, and apoptosis was analyzed by in situ terminal dUTP nick end labeling TUNEL assay. The intracellular reactive oxygen species (ROS) was measured in the isolated macrophages by fluorescence measurement with dichlorofluorescein diacetate (DCFH-DA). LPS-induced oxidative burst and apoptosis at 72 hours were reduced by both porcine and synthetic surfactant. SP-A as well as COX-1 and -2 expressions were suppressed with synthetic surfactant treatment, whereas with porcine surfactant (P-SF) the SP-A expression was enhanced in response to LPS administration. These results indicate that exogenous surfactant inhibits LPS-induced inflammation. This anti-inflammatory activity may be an important outcome of surfactant therapy in endotoxin-induced respiratory distress.

CITADO POR
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  2. Mokra Daniela, Mokry Juraj, Tonhajzerova Ingrid, Anti-inflammatory treatment of meconium aspiration syndrome: Benefits and risks, Respiratory Physiology & Neurobiology, 187, 1, 2013. Crossref

  3. Guo Liang, Li Shaoying, Zhao Yunfeng, Qian Pin, Ji Fuyun, Qian Lanlan, Wu Xueling, Qian Guisheng, Silencing Angiopoietin-Like Protein 4 (ANGPTL4) Protects Against Lipopolysaccharide-Induced Acute Lung Injury Via Regulating SIRT1 /NF-kB Pathway, Journal of Cellular Physiology, 230, 10, 2015. Crossref

  4. Mittal Neha, Sanyal Sankar Nath, Surfactant blocks lipopolysaccharide signaling by inhibiting both NFκB and PARP activation in experimental ARDS, Molecular and Cellular Biochemistry, 354, 1-2, 2011. Crossref

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  7. Mittal Neha, Sanyal Sankar Nath, Effect of exogenous surfactant on phosphatidylinositol 3-kinase-Akt pathway and peroxisome proliferator activated receptor-γ during endotoxin induced acute respiratory distress syndrome, Molecular and Cellular Biochemistry, 361, 1-2, 2012. Crossref

  8. Jung Hyun-Joo, Moon Jeong-Su, Park A Rum, Choi Hojin, Lee Jong Eun, Choi Seong-Hyun, Lim Chang-Jin, Anti-inflammatory, antinociceptive and anti-angiogenic activities of a phospholipid mixture purified from porcine lung tissues, Immunopharmacology and Immunotoxicology, 34, 3, 2012. Crossref

  9. Liu Jiao, Li Guang, Xie Wen-Jie, Wang Lu, Zhang Rui, Huang Ke-Sheng, Zhou Qing-Shan, Chen De-Chang, Lipopolysaccharide Stimulates Surfactant Protein-A in Human Renal Epithelial HK-2 Cells through Upregulating Toll-like Receptor 4 Dependent MEK1/2-ERK1/2-NF-κB Pathway, Chinese Medical Journal, 130, 10, 2017. Crossref

  10. Ruemmler Robert, Ziebart Alexander, Britten Elisabeth, Kamuf Jens, Garcia-Bardon Andreas, Hartmann Erik Kristoffer, Targeted fibre-optical intrabronchial lipopolysaccharide administration in pigs – a methodical refinement for improved accuracy in respiratory research, Veterinary Anaesthesia and Analgesia, 48, 1, 2021. Crossref

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  12. Kim Su-Young, Kim Yu-jin, Lee Esther, Choi Seong Hyun, Moon Jeong Su, An Hyo Sil, Ji Eun Su, Na Jungtae, Kim Beom Joon, Phospholipid fraction has protective effect by improving inflammation and skin barrier function in ischemia-reperfusion injury in mice, All Life, 13, 1, 2020. Crossref

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