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Journal of Environmental Pathology, Toxicology and Oncology
Fator do impacto: 1.241 FI de cinco anos: 1.349 SJR: 0.356 SNIP: 0.613 CiteScore™: 1.61

ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.v21.i4.10
54 pages

Escape Mechanisms in Tumor Immunity: An Update

Ludmila Muller
Tubingen Aging and Tumour Immunology Group (TATI), Section for Transplantation Immunology, Medizinische
Rolf Kiessling
Department of Oncology-Pathology, Karolinska Institutet, S-17176 Stockholm, Sweden
Robert C. Rees
Department of Life Sciences, Faculty of Science and Mathematics, The Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, England
Graham Pawelec
Tubingen Aging and Tumour Immunology Group (TATI), Section for Transplantation Immunology, Medizinische, Center for Medical Research, University of Tuebingen, Tuebingen, Germany

RESUMO

Evidence that tumors are immunogenic continues to accumulate. Although they frequently do express antigens in a form recognizable by the host immune system, tumors commonly “escape” the immune response. Tumors may therefore progress by evolving variants that can evade immune responses or by developing other strategies to avoid immune control. The purpose of this review is to consider the current status of knowledge concerning these different tumor-escape strategies, in the form of an update of previous publications in this journal.


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