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Journal of Environmental Pathology, Toxicology and Oncology
Fator do impacto: 1.625 FI de cinco anos: 1.63 SJR: 0.402 SNIP: 0.613 CiteScore™: 2.3

ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537

Journal of Environmental Pathology, Toxicology and Oncology

DOI: 10.1615/JEnvironPatholToxicolOncol.2018025264
pages 43-52

Pharmacological Evaluation of Novel Flavone from Morus alba in Pentylenetetrazole-Induced Kindling and Oxidative Stress

Bin Wang
Department of Pharmacy, The Fifth Hospital of Jinan, Shandong, 250022, China
Gaurav Gupta
School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Jaipur, India
Mahaveer Singh
School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, India
Kasturi Vishwanatha Setty Veerabhadrappa
Raghavendra Institute of Pharmaceutical Education and Research, K.R. Palli Cross, Chiyyedu, Anantapuramu-515752, Andhra Pradesh, India
Anurag Mishra
School of Pharmacy, Suresh Gyan Vihar University, Mahal Road, Jagatpura, Jaipur, India;
Gopala Krishna Chinnaboina
AM Reddy Memorial College of Pharmacy, Narasaraopet, Guntur, 522601, Andhra Pradesh, India

RESUMO

The present study was designed to explore the effect of chronic administration of a new flavone [morusflavone, 5,7,4’-trihydroxy-8-(γ,γ-dimethylallyl)-2’,3’-(10’-hydroxy-9’,10’-dimethyl-cyclohex-8-enyl)-flavone (compound 1)] at doses of 25, 50, and 100 mg/kg, orally (p.o.) to pentylenetetrazole-induced kindling in rats (a model of human epilepsy). Compound 1 and four other compounds were isolated from the stem bark of Morus alba. The structure of compound 1 was elucidated and established using standard spectroscopic techniques, and malondialdehyde (MDA) and glutathione (GSH) were estimated as oxidative markers in brain tissues of rodents. The progression of kindling in rats was effectively and significantly suppressed at doses of 25, 50, and 100 mg/kg of compound 1. In addition, increased the levels of MDA and decreased levels of glutathione were also reversed by compound 1 in kindled rats. Compound 1 treatment was able to restore the reduced glutathione level in the brain tissues of PTZ-kindled rats, thus proving its neuroprotective potential.


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