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Journal of Environmental Pathology, Toxicology and Oncology

Publicou 4 edições por ano

ISSN Imprimir: 0731-8898

ISSN On-line: 2162-6537

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 2.4 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.8 The Immediacy Index is the average number of times an article is cited in the year it is published. The journal Immediacy Index indicates how quickly articles in a journal are cited. Immediacy Index: 0.5 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00049 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.59 SJR: 0.429 SNIP: 0.507 CiteScore™:: 3.9 H-Index: 49

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Beneficial Protective Effect of Troxerutin on Nickel-Induced Renal Dysfunction in Wistar Rats

Volume 37, Edição 1, 2018, pp. 1-14
DOI: 10.1615/JEnvironPatholToxicolOncol.2017025087
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RESUMO

Nickel (Ni) is an important environmental toxicant that can cause cancer and cardiovascular disease. The aim of this study was to examine the protective effects of troxerutin (Txn) Ni-induced renal dysfunction in rats using biochemical and histopathological approaches. Nickel (20 mg/kg body weight [b.w.]/day) was administered intraperitoneally (i.p.) for 20 days. Renal damage from Ni toxicity was evident from the changed levels of serum and urinary markers in Ni-treated rats. The levels of lipid peroxidation markers also significantly increased, while the levels of nonenzymatic and enzymatic antioxidants significantly decreased in the kidney of Ni-intoxicated rats. Troxerutin was administered orally (100 mg/kg b.w.) for 20 days along with Ni, resulting in a reversal of Ni-induced biochemical changes in kidney accompanied by a significant decrease in lipid peroxidation and an increase in the level of renal antioxidant defense system. Histopathological studies in the kidneys of rats also showed that troxerutin (100 mg/ kg b.w.) markedly reduced the toxicity of Ni and preserved the normal histological architecture of the renal tissue. The present study results suggest the nephroprotective potential of Txn in Ni toxicity, which might be due to its antioxidant and metal-chelating properties.

CITADO POR
  1. Hosseinali Sara Haji, Boushehri Zahra Pourmokhtar, Rasti Behnam, Mirpour Mirsasan, Shahpasand Koorosh, Falahati Mojtaba, Biophysical, molecular dynamics and cellular studies on the interaction of nickel oxide nanoparticles with tau proteins and neuron-like cells, International Journal of Biological Macromolecules, 125, 2019. Crossref

  2. Fischer Rebecca S. B., Unrine Jason M., Vangala Chandan, Sanderson Wayne T., Mandayam Sreedhar, Murray Kristy O., Hu Yi, Evidence of nickel and other trace elements and their relationship to clinical findings in acute Mesoamerican Nephropathy: A case-control analysis, PLOS ONE, 15, 11, 2020. Crossref

  3. Salimi Ahmad, Jamali Zhaleh, Atashbar Saman, Khezri Saleh, Ghorbanpour Amir M., Etefaghi Nahid, Pathogenic Mechanisms and Therapeutic Implication in Nickel-Induced Cell Damage, Endocrine, Metabolic & Immune Disorders - Drug Targets, 20, 7, 2020. Crossref

  4. Zamanian Mohammad, Bazmandegan Gholamreza, Sureda Antoni, Sobarzo-Sanchez Eduardo, Yousefi-Manesh Hasan, Shirooie Samira, The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review, Current Neuropharmacology, 19, 1, 2020. Crossref

  5. Yin Heng, Zuo Zhicai, Yang Zhuangzhi, Guo Hongrui, Fang Jing, Cui Hengmin, Ouyang Ping, Chen Xia, Chen Jian, Geng Yi, Chen Zhengli, Huang Chao, Zhu Yanqiu, Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney, Ecotoxicology and Environmental Safety, 223, 2021. Crossref

  6. Ahmadi Zahra, Mohammadinejad Reza, Roomiani Sahar, Afshar Elham Ghasemipour, Ashrafizadeh Milad, Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View, Journal of Pharmacopuncture, 24, 1, 2021. Crossref

  7. Guo Hongrui, Yin Heng, Zuo Zhicai, Yang Zhuangzhi, Yang Yue, Wei Ling, Cui Hengmin, Deng Huidan, Chen Xia, Chen Jian, Zhu Yanqiu, Ouyang Ping, Geng Yi, Du Zongjun, Tang Huaqiao, Wang Fengyuan, Fang Jing, Oxidative stress-mediated apoptosis and autophagy involved in Ni-induced nephrotoxicity in the mice, Ecotoxicology and Environmental Safety, 228, 2021. Crossref

  8. Ajarem Jamaan S., Hegazy Ahmad K., Allam Gamal A., Allam Ahmed A., Maodaa Saleh N., Mahmoud Ayman M., Heavy Metal Accumulation, Tissue Injury, Oxidative Stress, and Inflammation in Dromedary Camels Living near Petroleum Industry Sites in Saudi Arabia, Animals, 12, 6, 2022. Crossref

  9. Alsawaf Seba, Alnuaimi Fatema, Afzal Saba, Thomas Rinku Mariam, Chelakkot Ayshwarya Lakshmi, Ramadan Wafaa S., Hodeify Rawad, Matar Rachel, Merheb Maxime, Siddiqui Shoib Sarwar, Vazhappilly Cijo George, Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation, Biology, 11, 12, 2022. Crossref

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