Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
Indexed in
Beneficial Protective Effect of Troxerutin on Nickel-Induced Renal Dysfunction in Wistar Rats
RESUMO
Nickel (Ni) is an important environmental toxicant that can cause cancer and cardiovascular disease. The aim of this study was to examine the protective effects of troxerutin (Txn) Ni-induced renal dysfunction in rats using biochemical and histopathological approaches. Nickel (20 mg/kg body weight [b.w.]/day) was administered intraperitoneally (i.p.) for 20 days. Renal damage from Ni toxicity was evident from the changed levels of serum and urinary markers in Ni-treated rats. The levels of lipid peroxidation markers also significantly increased, while the levels of nonenzymatic and enzymatic antioxidants significantly decreased in the kidney of Ni-intoxicated rats. Troxerutin was administered orally (100 mg/kg b.w.) for 20 days along with Ni, resulting in a reversal of Ni-induced biochemical changes in kidney accompanied by a significant decrease in lipid peroxidation and an increase in the level of renal antioxidant defense system. Histopathological studies in the kidneys of rats also showed that troxerutin (100 mg/ kg b.w.) markedly reduced the toxicity of Ni and preserved the normal histological architecture of the renal tissue. The present study results suggest the nephroprotective potential of Txn in Ni toxicity, which might be due to its antioxidant and metal-chelating properties.
-
Hosseinali Sara Haji, Boushehri Zahra Pourmokhtar, Rasti Behnam, Mirpour Mirsasan, Shahpasand Koorosh, Falahati Mojtaba, Biophysical, molecular dynamics and cellular studies on the interaction of nickel oxide nanoparticles with tau proteins and neuron-like cells, International Journal of Biological Macromolecules, 125, 2019. Crossref
-
Fischer Rebecca S. B., Unrine Jason M., Vangala Chandan, Sanderson Wayne T., Mandayam Sreedhar, Murray Kristy O., Hu Yi, Evidence of nickel and other trace elements and their relationship to clinical findings in acute Mesoamerican Nephropathy: A case-control analysis, PLOS ONE, 15, 11, 2020. Crossref
-
Salimi Ahmad, Jamali Zhaleh, Atashbar Saman, Khezri Saleh, Ghorbanpour Amir M., Etefaghi Nahid, Pathogenic Mechanisms and Therapeutic Implication in Nickel-Induced Cell Damage, Endocrine, Metabolic & Immune Disorders - Drug Targets, 20, 7, 2020. Crossref
-
Zamanian Mohammad, Bazmandegan Gholamreza, Sureda Antoni, Sobarzo-Sanchez Eduardo, Yousefi-Manesh Hasan, Shirooie Samira, The Protective Roles and Molecular Mechanisms of Troxerutin (Vitamin P4) for the Treatment of Chronic Diseases: A Mechanistic Review, Current Neuropharmacology, 19, 1, 2020. Crossref
-
Yin Heng, Zuo Zhicai, Yang Zhuangzhi, Guo Hongrui, Fang Jing, Cui Hengmin, Ouyang Ping, Chen Xia, Chen Jian, Geng Yi, Chen Zhengli, Huang Chao, Zhu Yanqiu, Nickel induces autophagy via PI3K/AKT/mTOR and AMPK pathways in mouse kidney, Ecotoxicology and Environmental Safety, 223, 2021. Crossref
-
Ahmadi Zahra, Mohammadinejad Reza, Roomiani Sahar, Afshar Elham Ghasemipour, Ashrafizadeh Milad, Biological and Therapeutic Effects of Troxerutin: Molecular Signaling Pathways Come into View, Journal of Pharmacopuncture, 24, 1, 2021. Crossref
-
Guo Hongrui, Yin Heng, Zuo Zhicai, Yang Zhuangzhi, Yang Yue, Wei Ling, Cui Hengmin, Deng Huidan, Chen Xia, Chen Jian, Zhu Yanqiu, Ouyang Ping, Geng Yi, Du Zongjun, Tang Huaqiao, Wang Fengyuan, Fang Jing, Oxidative stress-mediated apoptosis and autophagy involved in Ni-induced nephrotoxicity in the mice, Ecotoxicology and Environmental Safety, 228, 2021. Crossref
-
Ajarem Jamaan S., Hegazy Ahmad K., Allam Gamal A., Allam Ahmed A., Maodaa Saleh N., Mahmoud Ayman M., Heavy Metal Accumulation, Tissue Injury, Oxidative Stress, and Inflammation in Dromedary Camels Living near Petroleum Industry Sites in Saudi Arabia, Animals, 12, 6, 2022. Crossref
-
Alsawaf Seba, Alnuaimi Fatema, Afzal Saba, Thomas Rinku Mariam, Chelakkot Ayshwarya Lakshmi, Ramadan Wafaa S., Hodeify Rawad, Matar Rachel, Merheb Maxime, Siddiqui Shoib Sarwar, Vazhappilly Cijo George, Plant Flavonoids on Oxidative Stress-Mediated Kidney Inflammation, Biology, 11, 12, 2022. Crossref