Publicou 4 edições por ano
ISSN Imprimir: 0731-8898
ISSN On-line: 2162-6537
IF:
2.4
5-Year IF:
2.8
Immediacy Index:
0.5
Eigenfactor:
0.00049
JCI:
0.59
SJR:
0.429
SNIP:
0.507
CiteScore™::
3.9
H-Index:
49
Indexed in
Abrogation of Thioacetamide-Induced Biochemical Events of Hepatic Tumor Promotion Stage by Tannic Acid in Wistar Rats
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RESUMO
Tannic acid is present in almost every edible plant and is generally used as a safe food additive. In this study we investigated the antioxidative and antihyperproliferative potential of tannic acid against thioacetoamide (TAA), a potent hepatotoxic-substance-induced oxidative stress and hyperproliferation biomarker. We have shown here that the activities of hepatic antioxidant enzymes, phase II metabolizing enzymes, and the glutathione content were decreased while hepatic ornithine decarboxylase activity and DNA synthesis were induced in TAA-treated animals. Tannic acid administration at two different doses prior to the TAA injection partially recovered the depleted level of glutathione, inhibited activities of antioxidant and phase II metabolizing enzymes, and resulted in significant inhibition of oxidative stress in a dose-dependent manner. Tannic acid administration before TAA treatment also resulted in a significant decrease in ODC activity and [3H]-thymidine incorporation in rat liver, which are classical markers of inflammation and tumor promotion. Our data clearly demonstrate that tannic acid possesses antioxidant and antiproliferating activities because it inhibits early biomarkers of TAA-induced tumor promotion in an in vivo animal model.
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Afonso Jordao Alceu, Lima Sanchez Sheila Cristina, Vannucchi Portari Guilherme, Aparecida Domenici Fernanda, Vannucchi Helio, Vitamin E and tannic acid improve DNA damage in rats submitted chronic ethanol administration, British Food Journal, 112, 6, 2010. Crossref
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Nafees S, Ahmad ST, Arjumand W, Rashid S, Ali N, Sultana S, Carvacrol ameliorates thioacetamide-induced hepatotoxicity by abrogation of oxidative stress, inflammation, and apoptosis in liver of Wistar rats, Human & Experimental Toxicology, 32, 12, 2013. Crossref
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Pithayanukul Pimolpan, Nithitanakool Saruth, Bavovada Rapepol, Hepatoprotective Potential of Extracts from Seeds of Areca catechu and Nutgalls of Quercus infectoria, Molecules, 14, 12, 2009. Crossref
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Wang Zuo, Yin Lei, Liu Lei, Lan Xinyi, He Jianhua, Wan Fachun, Shen Weijun, Tang Shaoxun, Tan Zhiliang, Yang Yanming, Tannic acid reduced apparent protein digestibility and induced oxidative stress and inflammatory response without altering growth performance and ruminal microbiota diversity of Xiangdong black goats, Frontiers in Veterinary Science, 9, 2022. Crossref
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Wang Zuo, Zhao Yuan, Lan Xinyi, He Jianhua, Wan Fachun, Shen Weijun, Tang Shaoxun, Zhou Chuanshe, Tan Zhiliang, Yang Yanming, Tannic acid supplementation in the diet of Holstein bulls: Impacts on production performance, physiological and immunological characteristics, and ruminal microbiota, Frontiers in Nutrition, 9, 2022. Crossref